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Chronic inflammation as a potential mediator between phthalate exposure and depressive symptoms. | LitMetric

Chronic inflammation as a potential mediator between phthalate exposure and depressive symptoms.

Ecotoxicol Environ Saf

Department of Toxicology, School of Public Health, Anhui Medical University, China; Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes, China; Department of Maternal, Child and Adolescent Health Care, School of Public Health, Anhui Medical University, China; Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People's Republic of China, China. Electronic address:

Published: March 2022

AI Article Synopsis

  • The study investigates the link between phthalate exposure, specifically Mono (2-ethylhexyl) phthalate (MEHP), Mono benzyl phthalate (MBzP), and Mono butyl phthalate (MBP), and depressive symptoms in the elderly.
  • Using a sample of 989 elderly participants, researchers measured phthalate levels in urine and inflammatory factors in blood, finding a positive association between high phthalate levels and increased depressive symptoms.
  • Chronic inflammation was identified as a partial mediator in the relationship between MEHP exposure and depressive symptoms, suggesting that inflammation may play a role in how phthalates contribute to depression among older adults.

Article Abstract

Background: A few studies have reported phthalate exposure as a risk factor for depressive symptoms, but the results have been inconsistent. Whether chronic inflammation mediates the relationship between phthalates (PAEs) and depressive symptoms remains unclear. In this study, we establish mediating models of inflammatory factors and explore the mediating role of chronic inflammation in the association between PAEs exposure and depressive symptoms.

Methods: The sample included 989 participants from the Study on Health and Environment of the Elderly in Lu'an City, Anhui Province. Geriatric depression scale (GDS-30) was used to screen depressive symptoms of the elderly. The levels of seven kinds of PAEs in urine samples and four inflammatory factors in serum of the elderly were measured. To establish the mediating effect of inflammatory factors to explore the potential effect of PAEs exposure on the increased odds of depressive symptoms.

Results: Adjusted for multiple variables, the highest tertiles of Mono (2-ethylhexyl) phthalate (MEHP) (95%CI = 1.051-2.112), Mono benzyl phthalate (MBzP) (95%CI = 1.016-2.082) and Mono butyl phthalate (MBP) (95%CI = 1.102-2.262) were positively correlated with depressive symptoms. The mediating effect of IL-6 and generalized inflammation factor between MEHP exposure and depressive symptoms were 15.96% (95%CI=0.0288-0.1971) and 14.25% (95%CI = 0.0167-0.1899).

Conclusions: High levels of MEHP, MBzP and MBP increased the odds of depressive symptoms in the elderly, and chronic inflammation had a partial mediating effect on the increased odds of depressive symptoms due to MEHP exposure.

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Source
http://dx.doi.org/10.1016/j.ecoenv.2022.113313DOI Listing

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