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[T-gamma lymphocytosis associated with two solid neoplasms in a patient with rheumatoid arthritis].
An Med Interna
June 1998
Servicio de Hematología, Hospital Virgen de la Arrixaca, Murcia.
T gamma lymphocytosis is an infrequent entity, generally benign and distinct of the spectrum of the T cell chronic lymphoproliferative syndromes, that it not need or need short therapy, with a prolongated survival. T gamma lymphocytosis is expressive in the most of the occasions of a monoclonal lymphocytic proliferation and it is frequently associated to Rheumatoid Arthritis. We present the case of a patient with T gamma lymphocytosis, developed after several years of evolution of Rheumatoid Arthritis and that it was coincident with two solid neoplasms, an infiltrate carcinoma of the larynx and recurrent urothelial carcinoma, without previous chemotherapy.
View Article and Find Full Text PDF[Molecular analysis in 23 patients with T-lymphomas].
Sangre (Barc)
April 1991
Departamento de Genética, Fundación Jiménez Díaz, Madrid.
Gene rearrangement analysis has been performed in 23 patients with T-cell lymphoproliferative diseases: 4 cases with T-gamma lymphocytosis, one case of a Sezary's syndrome, one case of T-cell angioimmunoblastic lymphoma, two cases of T-cell lymphoepitheloid lymphoma, 11 patients with T-cell pleomorphic lymphoma, 3 cases of large anaplastic T-cell lymphoma and one case of T-cell lymphoblastic lymphoma. Rearranged banding patterns have been observed for at least one of the T-cell receptors (TCR) in 19 of the cases, and germ line configuration of the TCR and Ig genes in the other four. Likewise, both Ig and TCR rearrangements have been observed in three cases (one case of T-cell pleomorphic lymphoma, one case of large anaplastic T-cell lymphoma and one case of T-cell lymphoblastic lymphoma).
View Article and Find Full Text PDFImmunophenotypic and Gene Rearrangement Analysis in Null- or T-Cell Neoplasias: Study of 16 Cases.
Leuk Lymphoma
July 2016
a Department of Genetics, Fundaciòn Jimènez Diaz. Universidad Autònoma, Madrid, Spain.
Immunophenotypic and molecular studies were performed in sixteen cases of T-cell lymphoproliferative disorders. These included eleven patients with peripheral T-cell lymphoma, two thymic lymphomas and three patients with T-gamma lymphocytosis. Peripheral T-cell lymphomas were of both low and high grades.
View Article and Find Full Text PDFT gamma lymphocytosis and T cell chronic leukemias.
Hematol Oncol Clin North Am
April 1990
Yale Medical School, New Haven, Connecticut.
The T cell chronic leukemias encompass a broad spectrum of diseases involving mature post-thymic T cells. With the development of highly specific marker studies, clear patterns of immunophenotypic and functional characteristics of the involved cells have emerged. These studies, along with the development of molecular probes for the T cell receptor gene loci, have helped to elucidate the pathogenetic basis for the highly variable clinical course which has been described for patients with these disorders.
View Article and Find Full Text PDFFunctional analysis of clonally expanded CD8, TCR gamma delta T cells in a patient with chronic T-gamma lymphoproliferative disease.
Leuk Res
August 1990
Department of Internal Medicine, Shimane Medical University, Izumo, Japan.
Leukemic cells from a patient with T-gamma lymphocytosis were found to have the surface phenotype, CD3+, CD4-, CD8+, Leu19+, TCR delta 1+, WT31-. The clonal nature of the TCR gamma delta T cell proliferation was documented by flow cytometry and Southern blot analysis. Morphologically, they were large to medium-sized mature lymphocytes with cytoplasmic granules.
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