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Microsurgical Repair of Large Nasal Septal Defects: Microsurgical Repair of Large Nasal Septal Defects.
Ann Plast Surg
January 2025
Division of Plastic Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL.
Background: Nasal septal defects cause considerable morbidity and represent a challenging reconstructive problem. Traditional repair techniques have employed local intranasal tissues and allograft adjuncts. For large septal defects (>4-5 cm2), less than half are successfully resolved.
View Article and Find Full Text PDFImmune evasion through mitochondrial transfer in the tumour microenvironment.
Nature
January 2025
Division of Cell Therapy, Chiba Cancer Center Research Institute, Chiba, Japan.
Cancer cells in the tumour microenvironment use various mechanisms to evade the immune system, particularly T cell attack. For example, metabolic reprogramming in the tumour microenvironment and mitochondrial dysfunction in tumour-infiltrating lymphocytes (TILs) impair antitumour immune responses. However, detailed mechanisms of such processes remain unclear.
View Article and Find Full Text PDFYearling laryngeal function grades II.2 and below are not associated with reduced performance.
Equine Vet J
January 2025
School of Animal and Veterinary Sciences, University of Adelaide, Adelaide, South Australia, Australia.
Background: The relationship between Thoroughbred yearling laryngeal function (YLF) grade and race performance is unclear.
Objectives: To determine the effect of YLF on future race performance.
Study Design: Retrospective cohort study.
Convolutional neural networks for accurate real-time diagnosis of oral epithelial dysplasia and oral squamous cell carcinoma using high-resolution in vivo confocal microscopy.
Sci Rep
January 2025
Melbourne Dental School, University of Melbourne, Level 5, 720 Swanston Street, Carlton, Melbourne, VIC, 3053, Australia.
Oral cancer detection is based on biopsy histopathology, however with digital microscopy imaging technology there is real potential for rapid multi-site imaging and simultaneous diagnostic analysis. Fifty-nine patients with oral mucosal abnormalities were imaged in vivo with a confocal laser endomicroscope using the contrast agents acriflavine and fluorescein for the detection of oral epithelial dysplasia and oral cancer. To analyse the 9168 images frames obtained, three tandem applied pre-trained Inception-V3 convolutional neural network (CNN) models were developed using transfer learning in the PyTorch framework.
View Article and Find Full Text PDFSpontaneous immobilization of single atom in NbCT MXene as excellent nanozyme for detecting and preventing gastric mucosal injury.
Biosens Bioelectron
January 2025
Key Laboratory of Organic Integrated Circuit, Ministry of Education & Tianjin Key Laboratory of Molecular Optoelectronic Sciences, Department of Chemistry, School of Science, Tianjin University, Tianjin, 300072, China. Electronic address:
Early diagnosis and treatment of gastric mucosal injury is crucial to prevent further gastritis and even canceration. As an efficient biocatalyst, single-atom nanozyme (SAzyme) is proposed to be an ideal candidate for the construction of multifunctional platforms. Nevertheless, SAzyme still faces challenges in detecting and treating diseases due to the complexity of preparation methods, limitations of enzyme activity, and undesirable biocompatibility.
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