Lower and middle-income countries seldom develop vaccines and therapeutics for their own populations and are dependent on supplies from industrialized countries, which are often hampered by financial or supply chain limitations. This has resulted in major delays in delivery with significant loss of life, as seen with the coronavirus pandemic. Since the vast majority of deaths from the antimicrobial resistance crisis are expected to occur in developing countries, there is an urgent need for in-country production of antibacterial therapies such as phages. Nationally controlled phage banks might provide such a solution since locally developed phage therapies tailored to endemic bacterial strains could offer cost-effective antibiotic alternatives.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8846552 | PMC |
http://dx.doi.org/10.1016/j.coviro.2022.101208 | DOI Listing |
Infect Dis Rep
November 2024
Drug Discovery and Development, Creative Biolabs Inc., Shirley, NY 11967, USA.
Background: Phage therapy, a treatment utilizing bacteriophages to combat bacterial infections, is gaining attention as a promising alternative to antibiotics, particularly for managing antibiotic-resistant bacteria. This study aims to provide a comprehensive review of phage therapy by examining its safety, efficacy, influencing factors, future prospects, and regulatory considerations. The study also seeks to identify strategies for optimizing its application and to propose a systematic framework for its clinical implementation.
View Article and Find Full Text PDFDrug Resist Updat
November 2024
Department of Health, Nutrition, and Food Sciences, Florida State University, Tallahassee, 32306, United States. Electronic address:
The escalating global burden of antimicrobial resistance (AMR) represents a critical public health challenge. This rise in antibiotic resistance is concomitant with heightened antibiotic consumption, with an estimated annual usage of 100,000 to 200,000 tons. A recent systematic review, which analysed data from 204 countries, reported that AMR was responsible for 4.
View Article and Find Full Text PDFJ Environ Sci (China)
February 2025
Quebec Heart and Lung Institute Research Centre - Université Laval, 2725 Chemin Sainte-Foy, Quebec, G1V 4G5, Canada; Department of Biochemistry, Microbiology, and Bio-informatics, Faculty of Science and Engineering, Université Laval, 1045 Avenue de la Médecine, Quebec, G1V 0A6, Canada. Electronic address:
There are limited biosecurity measures directed at preventing airborne transmission of viruses in swine. The effectiveness of dust mitigation strategies such as oil sprinkling, to decrease risk of airborne virus transmission are unknown. Metagenomics and qPCR for common fecal viruses were used to hunt for a ubiquitous virus to serve as a proxy when evaluating the efficiency of mitigation strategies against airborne viral infectious agents.
View Article and Find Full Text PDFRNA
June 2024
Department of Biology, California Lutheran University, Thousand Oaks, California 91360, USA
RNA thermometers are highly structured noncoding RNAs located in the 5'-untranslated regions (UTRs) of genes that regulate expression by undergoing conformational changes in response to temperature. The discovery of RNA thermometers through bioinformatics is difficult because there is little sequence conservation among their structural elements. Thus, the abundance of these thermosensitive regulatory structures remains unclear.
View Article and Find Full Text PDFBiomedicines
February 2024
Institut Pasteur, Université Paris Cité, CNRS UMR6047, Bacteriophage Bacterium Host, 75015 Paris, France.
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!