Heart Transplant Donor Selection Guidelines: Review and Recommendations.

Curr Cardiol Rep

Heart and Vascular Institute, Pennsylvania State University, Milton S. Hershey Medical Center, Hershey, PA, USA.

Published: February 2022

Purpose Of Review: The rate of heart transplants, while steadily increasing, is insufficient to meet the growing list of transplant candidates. Marginal donors expand the donor pool. However, criteria used to identify donors greatly vary by institution.

Recent Findings: The International Society of Heart and Lung Transplant (ISHLT) heart transplant report of 2020 reinforced the importance of donor selection criteria on heart transplant outcomes. Existing literature challenges and reinforces the report's findings. Newer methods, such as donation after circulatory death (DCD), also recontextualize existing donor selection criteria. Transplant prediction models from international databases are poor predictors of individual centers' outcome. Further study is needed to understand associations among donor risk factors, and update the methods used for donor heart selection. In this review, we examine the current literature on extended donor criteria and recommend a model for donor selection.

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11886-021-01631-yDOI Listing

Publication Analysis

Top Keywords

donor selection
16
heart transplant
12
donor
8
selection criteria
8
heart
6
selection
5
transplant
5
transplant donor
4
selection guidelines
4
guidelines review
4

Similar Publications

Objectives: Transfusion-transmitted infections are a serious complication of blood transfusion. Devising a means of detecting at-risk blood donors may be beneficial in low- and middle-income countries such as Nigeria. We sought to determine the impact of ABO blood group on the prevalence of transfusion transmitted infections.

View Article and Find Full Text PDF

Background: The purpose of this study was to evaluate the present-day practices in the preparation, peri-, and postoperative care for patients undergoing autologous free flap breast reconstructions (ABR) worldwide, with the aim of enhancing informed decision-making for plastic surgeons during the planning stages of ABR.

Methods: A global survey was conducted among 280 plastic surgeons and 39 plastic and reconstructive surgery societies worldwide, enquiring about flap and donor site selection, surgical actions, perforator imaging, and perioperative care during ABR.

Results: Eighty-two responses were received, among which 71% (n=58) were completed questionnaires.

View Article and Find Full Text PDF

Introduction: Extensive scalp defects present a significant reconstructive challenge due to the complex needs of patients that are often beyond the scope of conventional therapies, which makes free flaps the most reliable solution. Despite the variety of free flaps available for such cases, there is a lack of clear criteria for selecting the most suitable option. The primary objective of this study was to provide a simplified guide for the selection of donor sites for free flaps for achieving optimal reconstruction outcomes.

View Article and Find Full Text PDF

Donor C1 Group KIR-ligand inferiority is linked to increased mortality in haploidentical hematopoietic stem cell transplantation with post-transplant cyclophosphamide.

Cytotherapy

December 2024

Department of Internal Medicine I: Hematology with Stem Cell Transplantation, Hemostaseology and Medical Oncology, Ordensklinikum Linz-Elisabethinen, Linz, Austria; Medical Faculty, Johannes Kepler University, Linz, Austria.

Background Aims: In HLA-identical hematopoietic stem cell transplantation (HSCT), HLA-C1 group killer cell immunoglobulin-like receptor (KIR) ligands have been linked to graft-versus-host disease, whereas C2 homozygosity was associated with increased relapses. The differential impact of the recipients versus the donor's HLA-C KIR ligands cannot be determined in HLA-identical HSCT but may be elucidated in the haploidentical setting, in which HLA-C (including the HLA-C KIR ligand group) mismatching is frequently present.

Methods: We retrospectively investigated the effect of recipient versus donor C1 ligand content on survival and complications in post-transplant cyclophosphamide (PTCy)-based haploidentical HSCT (n = 170).

View Article and Find Full Text PDF

Background: Mismatch between osteochondral allograft (OCA) donor and recipient sex has been shown to negatively affect outcomes. This study accounts for additional donor variables and clinically relevant outcomes.

Purpose: To evaluate whether donor sex, age, donor-recipient sex mismatch, and duration of graft storage affect clinical outcomes and failure rates after knee OCA transplantation.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!