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Deciphering endothelial heterogeneity in health and disease at single-cell resolution: progress and perspectives. | LitMetric

Deciphering endothelial heterogeneity in health and disease at single-cell resolution: progress and perspectives.

Cardiovasc Res

Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology and Leuven Cancer Institute (LKI), KU Leuven, VIB Center for Cancer Biology, VIB, Leuven, 3000, Belgium.

Published: March 2023

AI Article Synopsis

  • Endothelial cells (ECs) are crucial for maintaining blood vessel health and play significant roles in various diseases, making them important targets for therapy.
  • Recent advancements in single-cell research have unveiled the diverse subtypes of ECs, complicating their targeting and treatment in disease contexts.
  • This text reviews landmark studies that explore the genetic and metabolic factors influencing EC heterogeneity, discusses strategies for addressing disease-related EC characteristics, and highlights recent developments and challenges in single-cell analysis of ECs.

Article Abstract

Endothelial cells (ECs) constitute the inner lining of vascular beds in mammals and are crucial for homeostatic regulation of blood vessel physiology, but also play a key role in pathogenesis of many diseases, thereby representing realistic therapeutic targets. However, it has become evident that ECs are heterogeneous, encompassing several subtypes with distinct functions, which makes EC targeting and modulation in diseases challenging. The rise of the new single-cell era has led to an emergence of studies aimed at interrogating transcriptome diversity along the vascular tree, and has revolutionized our understanding of EC heterogeneity from both a physiological and pathophysiological context. Here, we discuss recent landmark studies aimed at teasing apart the heterogeneous nature of ECs. We cover driving (epi)genetic, transcriptomic, and metabolic forces underlying EC heterogeneity in health and disease, as well as current strategies used to combat disease-enriched EC phenotypes, and propose strategies to transcend largely descriptive heterogeneity towards prioritization and functional validation of therapeutically targetable drivers of EC diversity. Lastly, we provide an overview of the most recent advances and hurdles in single EC OMICs.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10022871PMC
http://dx.doi.org/10.1093/cvr/cvac018DOI Listing

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