AI Article Synopsis
- Hyperglycemia is linked to diabetic neuropathy and neuropathic pain, largely due to high levels of reactive oxygen species (ROS), while taxifolin, a flavonoid, can inhibit ROS production.
- The study aimed to examine the effect of taxifolin on hyperglycemia-induced neuropathy and pain in rats, which were divided into three groups: a healthy group, an alloxan-induced hyperglycemia group, and an alloxan plus taxifolin treatment group.
- Results showed that taxifolin significantly reduced hyperglycemia, improved pain thresholds, balanced oxidants and antioxidants, and preserved nerve tissue morphology, suggesting its potential to alleviate neuropathic symptoms associated with high blood sugar.
Article Abstract
Background: Hyperglycemia can be considered a determining factor in the development of diabetic neuropathy as well as neuropathic pain. There is a relationship between the excessive production of reactive oxygen species (ROS) and the pathogenesis of diabetic neuropathic pain. Taxifolin, on the other hand, is a flavonoid that has been documented to inhibit ROS production.
Objectives: To investigate the effects of taxifolin, which has antioxidant and neuroprotective effects, on alloxan-induced hyperglycemia-induced neuropathy and neuropathic pain, biochemically and histopathologically.
Material And Methods: The albino Wistar male rats were divided into 3 groups: healthy group (HG), only alloxan group (AXG) and alloxan+taxifolin group (ATG). Hyperglycemia in animals was caused through intraperitoneal injection of alloxan at a dose of 120 mg/kg. Paw pain thresholds of animals were measured using Basile algesimeter. Sciatic nerve tissues were examined biochemically and histopathologically in order to evaluate neuropathy.
Results: Our experimental results revealed that taxifolin significantly prevented the increase of plasma glucose concentration level with alloxan administration, the decrease of the paw pain threshold related to hyperglycemia, the change of oxidant-antioxidant balance in the sciatic nerve tissue in favor of oxidants, and the deterioration of tissue morphology in animals.
Conclusions: Our experimental results indicate that taxifolin alleviates alloxan-induced hyperglycemia-related neuropathy and neuropathic pain.
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| http://dx.doi.org/10.17219/acem/144002 | DOI Listing |
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