AI Article Synopsis
- Colorectal cancer is common globally, and this study investigates the link between P16 protein expression (an HPV infection marker) and colorectal cancer in Egyptian patients, focusing on its histopathological traits.
- Analyzing 59 colorectal cancer cases and 30 normal mucosa samples, the study found P16 expression in 22% of carcinoma cases but none in normal samples, with higher expression in distal tumors.
- The findings suggest that P16 protein is involved in colorectal cancer development, indicating the potential role of HPV in cancer progression, especially for distal colorectal tumors.
Article Abstract
Background: Colorectal cancer is one of the most prevalent types of tumors worldwide. P16ᴵᴺᴷ⁴ᵃ is a widely used immunohistochemical marker for high-risk HPV infection. The purpose of this study is to explore the relationship between P16 expression as an indicator of HPV infection and colorectal cancer in Egyptian patients, as well as its association with histopathological characteristics.
Material And Methods: The study was performed on 59 cases of colorectal carcinoma cases and 30 specimens of normal colonic mucosa.
Results: p16 protein was detected in 22% (13 of 59) of patients with colorectal carcinoma. No evidence of P16 expression in all 30 cases of non-neoplastic colonic mucosa was found. More frequent expression of P16 was seen in distal carcinomas.
Conclusion: our study demonstrated that P16 protein is expressed in a reasonable percent of colorectal carcinoma cases, suggesting a role of HPV in colorectal carcinogenesis. The present study highlights the role of p16 protein expression which is important in the pathogenesis in colorectal carcinoma, especially regarding distal tumors.
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| http://dx.doi.org/10.14670/HH-18-439 | DOI Listing |
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