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http://dx.doi.org/10.4244/EIJ-E-21-00008 | DOI Listing |
Mol Biol Cell
January 2025
Department of Molecular, Cellular, and Developmental Biology; University of Michigan; Ann Arbor, Michigan, 48109; USA.
To preserve barrier function, cell-cell junctions must dynamically remodel during cell shape changes. We have previously described a rapid tight junction repair pathway characterized by local, transient activation of RhoA, termed "Rho flares", which repair leaks in tight junctions via promoting local actomyosin-mediated junction remodeling. In this pathway, junction elongation is a mechanical trigger that initiates RhoA activation through an influx of intracellular calcium and recruitment of p115RhoGEF.
View Article and Find Full Text PDFJ Colloid Interface Sci
January 2025
School of Chemistry and Chemical Engineering, Chongqing University, Chongqing 401331, China. Electronic address:
Regulation of active sites of electrocatalysts is critical in adjusting electronic structure and catalytic selectivity towards oxygen reduction reaction (ORR) to hydrogen peroxide (HO). Herein, the CuX/CNTs (X = Se, SSe, S) hollow tetrakaidecahedron catalysts were synthesized to facilitate the electrocatalytic reduction of O to HO. The introduction of S resulted in a shift from four-electron pathway on CuSe/CNTs to two-electron process on CuS/CNTs, ultimately leading to an enhancement in HO productivity.
View Article and Find Full Text PDFJ Med Chem
January 2025
School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei 110, Taiwan.
Since decades after temozolomide was approved, no effective drugs have been developed. Undoubtedly, blood-brain barrier (BBB) penetration is a severe issue that should be overcome in glioblastoma multiforme (GBM) drug development. In this research, we were inspired by linezolid through structural modification with several bioactive moieties to achieve the desired brain delivery.
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