The stimulation of α-adrenoceptors caused a transient increase of intracellular calcium concentration ([Ca]) monitored by ratiometry using Fura-2 in epithelial cells including enterochromaffin cells in isolated mouse ileal crypts, while stimulation of α-and β-adrenoceptors had no effect. The effect of noradrenaline was suppressed by α-adrenoceptor antagonists, but not by α-and β-adrenoceptor antagonists, and partially suppressed by Ni and nicardipine, but not by ω-conotoxin and ω-agatoxin. These results suggest that noradrenaline causes an increase of [Ca] by the influx of extracellular Ca through certain Ca channels via α-adrenoceptors in epithelial cells of mouse ileal crypts.
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