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Significant Reduction in Vaccine-Induced Antibody Levels and Neutralization Activity Among Healthcare Workers and Nursing Home Residents 6 Months Following Coronavirus Disease 2019 BNT162b2 mRNA Vaccination. | LitMetric
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Significant Reduction in Vaccine-Induced Antibody Levels and Neutralization Activity Among Healthcare Workers and Nursing Home Residents 6 Months Following Coronavirus Disease 2019 BNT162b2 mRNA Vaccination.

David H Canaday Oladayo A Oyebanji Debbie Keresztesy Michael Payne Dennis Wilk Lenore Carias Htin Aung Kerri St Denis Evan C Lam Christopher F Rowley Sarah D Berry Cheryl M Cameron Mark J Cameron Brigid M Wilson Alejandro B Balazs Christopher L King Stefan Gravenstein

Clin Infect Dis

Division of Geriatrics and Palliative Medicine, Alpert Medical School of Brown University, Providence, Rhode Island, USA.

Published: August 2022

AI Article Synopsis

  • - Antibody levels in nursing home residents and healthcare workers dropped significantly (over 81%) from 2 weeks to 6 months after receiving the BNT162b2 mRNA vaccine.
  • - This decline occurred regardless of whether individuals had prior COVID-19 infections.
  • - Specifically, 69% of nursing home residents who had never been infected showed neutralizing antibody levels at or below the test's detection limit.

Article Abstract

Antibody decline occurred from 2 weeks to 6 months post-BNT162b2 mRNA vaccination in nursing home (NH) residents and healthcare workers. Antispike, receptor-binding domain, and neutralization levels dropped >81% irrespective of prior infection. Notably, 69% of infection-naive NH residents had neutralizing antibodies at or below the assay's limit of detection.

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 Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9402619PMC
http://dx.doi.org/10.1093/cid/ciab963DOI Listing

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