AI Article Synopsis
- - Population antibody surveillance in England, involving 212,102 vaccinated individuals, helps assess responses to COVID-19 vaccines and identifies factors influencing antibody levels.
- - Antibody positivity for both BNT162b2 and ChAdOx1 vaccines peaks 4-5 weeks after the first dose and generally declines over time; nearly 100% positivity is observed 21 days post second dose of BNT162b2, while ChAdOx1 shows lower rates, especially in older adults.
- - Higher antibody positivity is seen in younger individuals, females, and those with prior infection, while lower rates are noted in transplant recipients, obese individuals, smokers, and those with certain health conditions, indicating these groups may need extra vaccine doses.
Article Abstract
Population antibody surveillance helps track immune responses to COVID-19 vaccinations at scale, and identify host factors that may affect antibody production. We analyse data from 212,102 vaccinated individuals within the REACT-2 programme in England, which uses self-administered lateral flow antibody tests in sequential cross-sectional community samples; 71,923 (33.9%) received at least one dose of BNT162b2 vaccine and 139,067 (65.6%) received ChAdOx1. For both vaccines, antibody positivity peaks 4-5 weeks after first dose and then declines. At least 21 days after second dose of BNT162b2, close to 100% of respondents test positive, while for ChAdOx1, this is significantly reduced, particularly in the oldest age groups (72.7% [70.9-74.4] at ages 75 years and above). For both vaccines, antibody positivity decreases with age, and is higher in females and those with previous infection. Antibody positivity is lower in transplant recipients, obese individuals, smokers and those with specific comorbidities. These groups will benefit from additional vaccine doses.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8850615 | PMC |
| http://dx.doi.org/10.1038/s41467-022-28527-x | DOI Listing |
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