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| http://dx.doi.org/10.1186/s12913-022-07623-0 | DOI Listing |
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Target deconvolution is essential for elucidating the molecular mechanisms, therapeutic efficacy, and off-target toxicity of small-molecule drugs. Thermal proteome profiling (TPP) is a robust and popular method for identifying drug-protein interactions. Nevertheless, classical implementation of TPP using isobaric labeling of peptides is tedious, time-consuming, and costly.
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Department of Psychiatry, Autism Research Centre, University of Cambridge, 18B Trumpington Road, Cambridge, CB2 8AH, UK.
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Article Synopsis
- The study focused on reducing the "wastage rate" of blood components, which is the amount discarded compared to total collections, examining various factors affecting quality control and usability.
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Department of Medical Physics, Anna University, Chennai, Tamil Nadu, India.
Objective: To optimize the patient dose and image quality through quality assurance (QA) of diagnostic x-ray equipment and to ensure compliance with international and national standards in x-ray specification parameters, the use of contactless and quick non-invasive instruments has gained importance. Considering the importance of equipment qualification and the intervention level for equipment management, it is vital to account for uncertainties in the measurement of parameters in diagnostic radiology. However, the limits and measurement uncertainties associated with the parameter measurement are not well established and many technical and scientific literature provide different tolerance values, either as absolute or in terms of percentage.
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Indian Institute of Space Science & Technology, Valiamala, Kerala 695547, India.
A hybrid Monte-Carlo Gear solver developed earlier has been improvised to retrieve the vertical profiles of CH and NO during disturbed weather situations such as western disturbances, tropical cyclones, and heavy rainfall events over the megacities: Delhi, Kolkata, Chennai, and Mumbai. Due to rapid changes in the temperature during the passage of these systems over megacities, the percentage differences of CH and NO number concentrations were more compared to the Community Long-term Infrared Microwave Coupled Atmospheric Product System (CLIMCAPS). Therefore, the hybrid solver has been modified by improving maximum likelihood estimates of vertical temperature profiles.
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