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Molecular Characterization of Carbapenem-Resistant Enterobacterales Collected in the United States. | LitMetric

AI Article Synopsis

  • Carbapenem-resistant Enterobacterales (CRE) pose a significant public health risk due to their resistance to multiple antibiotics and a high potential for causing severe healthcare-associated infections.
  • In a study involving 421 CRE samples collected across eight U.S. sites, most were found in urine, with the most common organism being Escherichia coli.
  • Whole genome sequencing revealed that a significant majority (73%) of isolates carried a carbapenemase gene, with geographical variations in the prevalence of different species and sequence types, while most isolates still showed susceptibility to amikacin and tigecycline.

Article Abstract

Carbapenem-resistant Enterobacterales (CRE) are a growing public health concern due to resistance to multiple antibiotics and potential to cause health care-associated infections with high mortality. Carbapenemase-producing CRE are of particular concern given that carbapenemase-encoding genes often are located on mobile genetic elements that may spread between different organisms and species. In this study, we performed phenotypic and genotypic characterization of CRE collected at eight U.S. sites participating in active population- and laboratory-based surveillance of carbapenem-resistant organisms. Among 421 CRE tested, the majority were isolated from urine ( = 349, 83%). was the most common organism ( = 265, 63%), followed by complex ( = 77, 18%) and ( = 50, 12%). Of 419 isolates analyzed by whole genome sequencing, 307 (73%) harbored a carbapenemase gene; variants of predominated ( = 299, 97%). The occurrence of carbapenemase-producing , complex, and varied by region; the predominant sequence type within each genus was ST258, ST171, and ST131, respectively. None of the carbapenemase-producing CRE isolates displayed resistance to all antimicrobials tested; susceptibility to amikacin and tigecycline was generally retained.

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Source
http://dx.doi.org/10.1089/mdr.2021.0106DOI Listing

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