AI Article Synopsis
- In a study analyzing treatment interruptions in psoriasis patients, some individuals continued to experience positive outcomes even after halting their medication.
- Following a 12-week treatment with ixekizumab, patients who showed significant improvement had varying times before losing their treatment response when switched to placebo, with median times of 16.1 weeks for substantial improvement and 12.1 weeks for complete improvement.
- A minority of patients maintained their high levels of disease control long after treatment discontinuation, suggesting that not all patients will immediately lose effectiveness of previously successful treatments.
Article Abstract
In clinical practice, interruption of treatment may not result in immediate cessation of disease control, and some patients even experience sustained treatment response following treatment interruption. This post hoc analysis of UNCOVER-1 and -2 Phase 3 clinical trials characterized the time to loss of treatment response in patients with psoriasis who responded to ixekizumab through a 12-week treatment period, and who were then re-randomized to placebo for the following 48 weeks. For those with static Physician Global Assessment [sPGA]0/1 and Psoriasis Area and Severity Index [PASI]90 at Week 12, the median time to loss of PASI90 was 16.1 weeks (95% confidence interval 12.7-16.4). For those with PASI100 at Week 12, the median time to loss of PASI100 was 12.1 weeks (95% confidence interval 9.0-13.0). A small subset of patients maintained high levels of disease control through Week 60. This study adds to the growing body of evidence on sustained treatment response following treatment interruption.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9574691 | PMC |
| http://dx.doi.org/10.2340/actadv.v102.1984 | DOI Listing |
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