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Advances in Pure Drug Self-Assembled Nanosystems: A Novel Strategy for Combined Cancer Therapy.
Pharmaceutics
January 2025
Nanjing Medical Center for Clinical Pharmacy, Department of Pharmacy, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210008, China.
Nanoparticle-based drug delivery systems hold great promise for improving the effectiveness of anti-tumor therapies. However, their clinical translation remains hindered by several significant challenges, including intricate preparation processes, limited drug loading capacity, and concerns regarding potential toxicity. In this context, pure drug-assembled nanosystems (PDANSs) have emerged as a promising alternative, attracting extensive research interest due to their simple preparation methods, high drug loading efficiency, and suitability for large-scale industrial production.
View Article and Find Full Text PDFNano-Perforated Silicon Membrane with Monolithically Integrated Buried Cavity.
Micromachines (Basel)
January 2025
DTU Nanolab, National Centre for Nano Fabrication and Characterization, Technical University of Denmark, Ørsteds Plads B347, 2800 Kongens Lyngby, Denmark.
A wafer-scale process for fabricating monolithically suspended nano-perforated membranes (NPMs) with integrated support structures into silicon is developed. Existing fabrication methods are suitable for many desired geometries, but face challenges related to mechanical robustness and fabrication complexity. We demonstrate a process that utilizes the cyclic deposit, remove, etch, and multi-step (DREM) process for directional etching of high-aspect-ratio (HAR) 300 nm in diameter nano-pores of 700 nm pitch.
View Article and Find Full Text PDFA Landscape of Cancer Initiation and Cancer Stem Cells.
Cancers (Basel)
January 2025
Laboratory of Cancer Stem Cell Engineering, Faculty of Interdisciplinary Science and Engineering of Health Systems, Okayama University, 3-1-1 Tsushima-Naka, Kita-ku, Okayama 700-8530, Japan.
Exposure to radiation and chemicals, oncogenic viruses, microbiomes, and inflammation are the major events of cancer initiation. DNA damage and chromosomal aberrations are classically considered the main causes of cancer. The recent idea of epigenetics is broadening the concept, including the suggestion that oncogenic virus infection disrupts various intracellular signaling cascades.
View Article and Find Full Text PDF[Advances in the catalytic promiscuity of nitrilases].
Sheng Wu Gong Cheng Xue Bao
January 2025
College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310014, Zhejiang, China.
As important biocatalysts, nitrilases can efficiently convert nitrile groups into acids and ammonia in a mild and eco-friendly manner, being widely used in the synthesis of important pharmaceutical intermediates. Early studies reported that nitrilases only had the hydrolysis activity of catalyzing the formation of corresponding carboxylic acid products from nitriles, showing catalytic specificity. However, recent studies have shown that some nitrilases exhibit the hydration activity for catalyzing the formation of amides from nitriles, showing catalytic promiscuity.
View Article and Find Full Text PDFAdvancements in Superhydrophobic Paper-Based Materials: A Comprehensive Review of Modification Methods and Applications.
Nanomaterials (Basel)
January 2025
Qiqihar Inspection and Testing Center, Qiqihar 161006, China.
Superhydrophobic paper-based functional materials have emerged as a sustainable solution with a wide range of applications due to their unique water-repelling properties. Inspired by natural examples like the lotus leaf, these materials combine low surface energy with micro/nanostructures to create air pockets that maintain a high contact angle. This review provides an in-depth analysis of recent advancements in the development of superhydrophobic paper-based materials, focusing on methodologies for modification, underlying mechanisms, and performance in various applications.
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