Unconventional roles of lactate along the tumor and immune landscape.

Trends Endocrinol Metab

Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy; Tuscany Tumor Institute (ITT) and Excellence Centre for Research, Transfer and High Education DenoTHE, Florence, Italy. Electronic address:

Published: April 2022

The tumor ecosystem evolves with dynamic interactions between cancer and normal cells, and nutrients have emerged as new regulators of cancer hallmarks. Lactate has climbed the rankings as a multifunctional molecule orchestrating many aspects of the disease onset and progression. Here, we patchwork and discuss the main recent findings conferred during the EMBO workshop titled 'Lactate: Unconventional Roles of a Nutrient Along the Tumor Landscape.'

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Source
http://dx.doi.org/10.1016/j.tem.2022.01.005DOI Listing

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