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Patient choice as inclusion criterion for first clinical trials of xenotransplantation.
J Med Ethics
January 2025
Institute of Ethics, History and Theory of Medicine, LMU Munich, Munich, Germany
Ethical Implications of Social Science Research on Xenotransplantation.
Xenotransplantation
November 2024
Institute of Ethics, History and Theory of Medicine, LMU Munich, Munich, Germany.
Social science research has generated extensive knowledge on xenotransplantation, encompassing the perspectives of actual and potential patients, other stakeholders, public opinion and debate, human-animal relationships, animal production and husbandry, bioeconomy, as well as biotechnology governance and regulation. We therefore convened social science researchers to discuss the latest developments in xenotransplantation research and practice in late 2023. Based on a brief workshop report, we aim to highlight the various ethical implications of this debate.
View Article and Find Full Text PDFPig organs in humans: a forum on xenotransplantation.
Natl Sci Rev
October 2024
NSR news and science editor based in Beijing.
What if one of your organs, say, the kidney, the heart or the liver, deteriorates completely, and you are not lucky enough to have a human organ for transplantation? Do you want to receive an organ from a pig? That is not a joke, but a subject some physicians and researchers are working on-a field of research known as 'xenotransplantation'.In 2022, David Bennett, a 57-year-old patient with terminal heart disease, received a pig heart and survived for 2 months after the surgery. Another recipient, Lawrence Faucette, survived for 40 days after similar surgery in 2023.
View Article and Find Full Text PDFWho shall go first? A multicriteria approach to patient selection for first clinical trials of cardiac xenotransplantation.
J Med Ethics
September 2024
Institute of Ethics, History and Theory of Medicine, LMU Munich, Munich, Germany
After achieving sustained graft functioning in animal studies, the next step in the progression of xenotransplantation towards clinical application is the initiation of the first clinical trials. This raises the question according to which criteria patients shall be selected for these trials. While the discussion regarding medical criteria has already commenced, ethical considerations must also be taken into account.
View Article and Find Full Text PDFThe history of cardiac xenotransplantation: early attempts, major advances, and current progress.
Front Transplant
July 2023
Division of Cardiac Surgery, Department of Cardiothoracic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States.
In light of ongoing shortage of donor organs for transplantation, alternative sources for donor organ sources have been examined to address this supply-demand mismatch. Of these, xenotransplantation, or the transplantation of organs across species, has been considered, with early applications dating back to the 1600s. The purpose of this review is to summarize the early experiences of xenotransplantation, with special focus on heart xenotransplantation.
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