AI Article Synopsis
- A new method for nitrating electron-rich arenes using copper as a catalyst has been developed.
- The process involves trimethylsilyl chloride and guanidine nitrate, resulting in a range of nitrated products with yields between 32-99%.
- This reaction can be performed easily at room temperature without the need for harsh acids or complex setups.
Article Abstract
A practical copper-catalyzed nitration of electron-rich arenes with trimethylsilyl chloride and guanidine nitrate is reported. A variety of nitrated products were generated in moderate to excellent yields (32-99%) at ambient temperature under acid-free, open-flask, and operationally simple conditions.
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| http://dx.doi.org/10.1021/acs.joc.1c03020 | DOI Listing |
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