We demonstrate a high-power all-solid-state picosecond laser based on a passive mode-locking laser with a large-size rectangular core crystalline waveguide and a semiconductor saturable-absorber mirror. An average power of 16.9 W is achieved with a 1.96 ps duration and a 31.74 MHz repetition frequency. This is the first demonstration of a mode-locked laser with a large-size rectangular core crystalline waveguide to our knowledge.
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http://dx.doi.org/10.1364/OL.449687 | DOI Listing |
We report what we believe to be a novel circular-clad large-size rectangular core crystalline waveguide Yb:YAG laser. The waveguide has a rectangular core of Yb:YAG with 400 × 400 μm and a thin rod-shaped cladding of Er:YAG with a diameter of 1.2 mm and a length of 65 mm.
View Article and Find Full Text PDFACS Appl Mater Interfaces
February 2025
Department of Engineering Design, Indian Institute of Technology Madras, Chennai 600036, India.
This study presents a novel optoporation technique using a titanium-coated TiO microstructure (TMS) device activated by an infrared diode laser for highly efficient intracellular delivery. The TMS device, fabricated with 120 nm titanium coating on a titanium dioxide (TiO) microstructure containing microneedles (height ∼2 μm and width ∼4.5 μm), demonstrates enhanced biocompatibility and thermal conductivity compared to the conventional TiO microstructure (MS).
View Article and Find Full Text PDFAnalyst
February 2025
Department of Engineering Design, Indian Institute of Technology Madras, India.
High throughput intracellular delivery of biological macromolecules is crucial for cell engineering, gene expression, therapeutics, diagnostics, and clinical studies; however, most existing techniques are either contact-based or have throughput limitations. Herein, we report a light-activated, contactless, high throughput photoporation method for highly efficient and viable cell transfection of more than a million cells within a minute. We fabricated reduced graphene oxide (rGO) nanoflakes that was mixed with a polydimethylsiloxane (PDMS) nanocomposite thin sheet with an area of 3 cm and a thickness of ∼600 μm.
View Article and Find Full Text PDFThe ovary is one of the first organs to exhibit signs of aging, characterized by reduced tissue function, chronic inflammation, and fibrosis. Multinucleated giant cells (MNGCs), formed by macrophage fusion, typically occur in chronic immune pathologies, including infectious and non-infectious granulomas and the foreign body response , but are also observed in the aging ovary . The function and consequence of ovarian MNGCs remain unknown as their biological activity is highly context-dependent, and their large size has limited their isolation and analysis through technologies such as single-cell RNA sequencing.
View Article and Find Full Text PDFNanoscale
January 2025
Department of Chemistry, University at Buffalo, SUNY, New York 14260, USA.
Multiphoton upconversion lasing in scattering gain media has attracted considerable attention in recent years. LAPONITE® is a scattering medium consisting of 2-D nano-discs that can be dispersed as a transparent solution in aqueous media and forms a gel at high concentration. In this paper, we demonstrate two-photon pumped upconversion regular lasing along forward and backward directions as well as random lasing along all other directions.
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