An oxidative copper-mediated double trifluoromethylselenolation of terminal 2-alkynylanilines using [(bpy)CuSeCF] is reported, providing a moderately efficient and convenient approach to 2,3-bis(trifluoromethylseleno)indoles. Mechanistic studies show that a cascade sequence of oxidation, trifluoromethylselenolation, 5-- cyclization, and elimination is involved in this transformation.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/acs.joc.1c03156 | DOI Listing |
Publication Analysis
Top Keywords
oxidative copper-mediated
8
synthesis 23-bistrifluoromethylseleno
4
23-bistrifluoromethylseleno indoles
4
indoles oxidative
4
copper-mediated domino
4
domino reaction
4
reaction oxidative
4
copper-mediated double
4
double trifluoromethylselenolation
4
trifluoromethylselenolation terminal
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!