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Charlson comorbidity index predicts anastomotic leakage in patients with resected right-sided colon cancer. | LitMetric

AI Article Synopsis

  • * Patients with AL had significantly higher rates of comorbidities, blood loss, and longer hospital stays compared to those without AL, along with higher instances of specific chronic diseases.
  • * The Charlson comorbidity index (CCI) score was determined to be a strong independent predictor of postoperative AL, indicating that a higher CCI (≥2) increases the risk of developing this complication.

Article Abstract

Purpose: Anastomotic leakage after right-sided colon cancer surgery is a serious complication that affects postoperative mortality. The Charlson comorbidity index (CCI) has been reported to be a useful predictor of postoperative complications.

Methods: A total of 593 cases of right-sided colon cancer resections performed from 2016 to 2020 were examined. The patients were divided into two groups according to the presence or absence of anastomotic leakage (AL, n = 28; no-AL, n = 565); clinicopathological and surgical characteristics were compared between the groups.

Results: The AL group patients had a higher comorbidity rate (96.4% vs. 66.9%, p < 0.001), higher CCI score (p < 0.001), higher blood loss (42 mL vs. 23 mL, p = 0.046), and longer hospital stay (30 days vs. 12 days, p < 0.001) than the no-AL group patients. The percentages of chronic pulmonary disease (14.3% vs. 3.9%, p = 0.029), cerebrovascular disease (14.3% vs. 1.9%, p = 0.022), connective tissue disease (39.3% vs. 3.2%, p < 0.001), leukemia (3.6% vs. 0%, p = 0.042), and moderate to severe liver disease (7.1% vs. 0%, p = 0.002) were significantly higher in the AL group. In the multivariate analysis, CCI ≥ 2 was identified as an independent predictor of postoperative anastomotic leakage (hazard ratio 4.91, 95% confidence interval 2.23-10.85, p < 0.001).

Conclusions: CCI could predict anastomotic leakage after right-sided colon cancer surgery.

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Source
http://dx.doi.org/10.1007/s00595-022-02472-0DOI Listing

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