Background And Objective: Many patients are unable to initiate long-acting injectable naltrexone (XR-NTX) on a first attempt, due to the prerequisite abstinence and withdrawal from opioids.
Methods: Thirty patients who were unable to initiate XR-NTX were recruited to receive buprenorphine for 1 week, followed by a 3-week buprenorphine taper, and an ascending titration of oral naltrexone before XR-NTX injection.
Results: Eight (27%) initiated XR-NTX, 7 (23%) transitioned to buprenorphine maintenance treatment and 15 (50%) were lost to follow up.
Conclusion And Scientific Significance: A second attempt at XR- NTX initiation using buprenorphine stabilization and cross taper may be a reasonable approach for some patients.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9375774 | PMC |
| http://dx.doi.org/10.1097/ADM.0000000000000974 | DOI Listing |
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