AI Article Synopsis

  • - The study investigates the relationship between surgical methods (Mohs micrographic surgery vs. wide local excision) and outcomes (recurrence and survival) for Merkel cell carcinoma treatment.
  • - A comprehensive literature search resulted in the inclusion of 19 case series and 12 cohort studies, concluding that there are no significant differences in outcomes between the two surgical options or different excision margins.
  • - Ultimately, the findings suggest that both surgical approaches have similar recurrence and survival rates for Merkel cell carcinoma, indicating that the choice of method may not impact patient outcomes.

Article Abstract

Background: When treating Merkel cell carcinoma (MCC), the relation between wide local excision (WLE) margin and recurrence or survival is unclear. Mohs micrographic surgery (MMS) is an alternative surgical option for MCC, but it is unknown whether the local recurrence rate differs between MMS and WLE.

Objective: To systematically assess the available literature to determine the recurrence and survival rates when treating MCC with MMS and different clinical excision margins.

Materials And Methods: The MEDLINE, EMBASE, and CENTRAL databases were searched. Two independent reviewers selected studies that defined clear excision margins and either recurrence or survival. When possible, individual cases were extracted from case series and included in the analyses. Other studies were reviewed narratively.

Results: Overall, 1108 studies were identified; of which, 19 case series (168 cases) and 12 cohort studies were eligible. None of the cohort studies showed significant differences in recurrence or survival for either excision margins or MMS. Equally, logistic and Cox regression analyses of the case series revealed no significant differences in recurrence or survival between different excision margins and MMS.

Conclusion: Synthesis of the available data does not indicate differences in recurrence and/or survival rates for MCC between different clinical excision margins and MMS.

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Source
http://dx.doi.org/10.1097/DSS.0000000000003402DOI Listing

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