This study aims to investigate flaviviruses as an environmental factor in the etiology of nonsyndromic cleft lip and/or palate (CL/P). A scoring method with 7 topics-disease, transplacental passage, tropism, cellular damage, reported case, analysis of genome similarity, and transcriptome between virus and host, was created based on literature and experimentation. Viral genomes of NCBI virus were obtained and BLAST 2.12.0 was applied for the similarity analysis, adjusted to search for only human sequences related to CL/P with the statistical threshold defined for E-value ≤1. Flaviviruses with high potential to cause CL/P were: serotypes 2, 3, and 4 of the and lineage 2 of the , while the , , , and presented with medium potential to cause CL/P. As for the , even strains associated with microcephaly showed only medium potential. and presented with high potential to act as environmental factors in the etiology of CL/P.
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