Hafnium(IV) triflate (Hf(OTf)) has been identified as a potent catalyst for the direct three-component synthesis of β-carbamate ketones. This new method, featuring a low catalyst loading, fast reaction rate, and solvent-free conditions, provided facile access to a diversity of carbamate-protected Mannich bases. A mechanistic investigation indicated that the three-component reaction proceeds via sequential aldol condensation and aza-Michael addition, but not the Mannich-type pathway.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8840004 | PMC |
| http://dx.doi.org/10.3390/molecules27031122 | DOI Listing |
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