The Role of Biomaterials in Peripheral Nerve and Spinal Cord Injury: A Review.

Int J Mol Sci

Faculty of Biomedical Engineering, Technion-Israel Institute of Technology, Haifa 3200003, Israel.

Published: January 2022

Peripheral nerve and spinal cord injuries are potentially devastating traumatic conditions with major consequences for patients' lives. Severe cases of these conditions are currently incurable. In both the peripheral nerves and the spinal cord, disruption and degeneration of axons is the main cause of neurological deficits. Biomaterials offer experimental solutions to improve these conditions. They can be engineered as scaffolds that mimic the nerve tissue extracellular matrix and, upon implantation, encourage axonal regeneration. Furthermore, biomaterial scaffolds can be designed to deliver therapeutic agents to the lesion site. This article presents the principles and recent advances in the use of biomaterials for axonal regeneration and nervous system repair.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8835501PMC
http://dx.doi.org/10.3390/ijms23031244DOI Listing

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