Incremental sheet metal forming characterized as increased flexibility and local plastic deformation is well suitable for low-production-run manufacturing and a new sample trial production of complex shapes. Thickness thinning is still an obstacle to the application of incremental forming. In this study, a novel mathematical algorithm based on a non-uniform rational B-spline (NURBS) surface was proposed and implemented which focuses on predicting and calculating the final thickness for arbitrary parts in incremental forming. In order to evaluate the validity of the proposed model, the finite element simulation and forming experiments of three kinds of parts, such as truncated cones, truncated pyramids and ellipsoid parts, were conducted. The thickness of theoretical prediction was compared with that of finite element simulation and experiment, and good agreements were obtained. The results show that the proposed model and the method are effective and robust for predicting the thickness of the formed parts in incremental sheet metal forming.
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http://dx.doi.org/10.3390/ma15031201 | DOI Listing |
Diabetologia
January 2025
MRC Epidemiology Unit, School of Clinical Medicine, University of Cambridge, Cambridge, UK.
Aims/hypothesis: UK standard care for type 2 diabetes is structured diabetes education, with no effects on HbA, small, short-term effects on weight and low uptake. We evaluated whether remotely delivered tailored diabetes education combined with commercial behavioural weight management is cost-effective compared with current standard care in helping people with type 2 diabetes to lower their blood glucose, lose weight, achieve remission and improve cardiovascular risk factors.
Methods: We conducted a pragmatic, randomised, parallel two-group trial.
Phytomedicine
January 2025
Post-graduate Department of Biotechnology, Utkal University, Bhubaneswar, 751004, Odisha, India.; Centre of Excellence in Integrated Omics and Computational Biology, Utkal University, Bhubaneswar 751004, Odisha, India.. Electronic address:
Background: Cardiovascular diseases (CVDs) are the major contributor to global mortality and are gaining incremental attention following the COVID-19 outbreak. Epigenetic events such as DNA methylation, histone modifications, and non-coding RNAs have a significant impact on the incidence and onset of CVDs. Altered redox status is one of the major causative factors that regulate epigenetic pathways linked to CVDs.
View Article and Find Full Text PDFAppl Health Econ Health Policy
January 2025
Centre for Health Economics, University of York, Alcuin 'A' Block, Heslington, York, YO10 5DD, UK.
Objectives: The UK has recently established subscription-payment agreements for two antimicrobials: cefiderocol and ceftazidime-avibactam. This article summarises the novel value assessments that informed this process and lessons learned for future pricing and funding decisions.
Methods: The evaluations used decision modelling to predict population incremental net health effects (INHEs), informed by systematic reviews, evidence syntheses, national surveillance data and structured expert elicitation.
Materials (Basel)
November 2024
Forming Laboratory, Faculty of Mechanical Engineering, University of Ljubljana, Aškerčeva 6, 1000 Ljubljana, Slovenia.
Flexibility is crucial in forming processes as it allows the production of different product shapes without changing equipment or tooling. Single-point incremental forming (SPIF) provides this flexibility, but often results in excessive sheet metal thinning. To solve this problem, a pre-forming phase can be introduced to ensure a more uniform thickness distribution.
View Article and Find Full Text PDFJ Am Geriatr Soc
November 2024
Division of Epidemiology & Community Health, School of Public Health, Minneapolis, Minnesota, USA.
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