AI Article Synopsis

  • The study analyzed long-term mortality rates in heart failure outpatients based on different causes of the condition, involving 2,587 patients admitted to a heart failure clinic over 18 years.
  • Among the 2,387 patients included in the final analysis, 1317 deaths were recorded, with ischemic heart disease (IHD) having the highest risk of cardiovascular (CV) death while dilated cardiomyopathy (DCM) showed a lower risk of all-cause death.
  • The findings suggest that DCM has the lowest risk for all-cause death, DICM has the highest risk, and almost all HF etiologies have a reduced risk of CV death compared to IHD.

Article Abstract

We assessed differences in long-term all-cause and cardiovascular (CV) mortality in heart failure (HF) outpatients based on the etiology of HF. Consecutive patients admitted to the HF Clinic from August 2001 to September 2019 ( = 2587) were considered for inclusion. HF etiology was divided into ischemic heart disease (IHD), dilated cardiomyopathy (DCM), hypertensive heart disease, alcoholic cardiomyopathy, drug-induced cardiomyopathy (DICM), valvular heart disease, and hypertrophic cardiomyopathy. All-cause death and CV death were the primary end points. Among 2387 patients included in the analysis (mean age 66.5 ± 12.5 years, 71.3% men), 1317 deaths were recorded (731 from CV cause) over a maximum follow-up of 18 years (median 4.1 years, interquartile range (IQR) 2-7.8). Considering IHD as the reference, only DCM had a lower risk of all-cause death (adjusted hazard ratio (aHR) 0.68, 95% confidence interval (CI) 0.56-0.83, < 0.001), and only DICM had a higher risk of all-cause death (aHR 1.47, 95% CI 1.02-2.11, = 0.04). However, almost all etiologies had a significantly lower risk of CV death than IHD. Among the studied HF etiologies, DCM and DICM have the lowest and highest risk of all-cause death, respectively, whereas IHD has the highest adjusted risk of CV death.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8837120PMC
http://dx.doi.org/10.3390/jcm11030784DOI Listing

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