Activity of -Based Silver Nanoparticles on spp. Oral Isolates.

spp. resistant to commercially available antifungals are often isolated from patients with oral candidiasis, a situation that points to the need for the development of new therapies. Thus, we evaluated the activity of -based silver nanoparticles (AgNPs) on spp. isolated from denture stomatitis lesions. isolates were molecularly identified and submitted to susceptibility assays using AgNPs and commercial fungicides. The interference on biofilm formation and the mechanisms of action of AgNPs on spp. were also investigated. Scanning electron microscopy was used to evaluate the morphology of AgNP-treated . was the most frequent species isolated from denture stomatitis cases. All spp. were susceptible to AgNPs at low concentrations, except . AgNPs caused surface damage, cell disruption, and biofilm formation inhibition. The ergosterol supplementation protected against the AgNP action. AgNPs are effective against spp. and can be faced as a promising new therapeutic agent against oral candidiasis.