AI Article Synopsis

  • * A study analyzed the health outcomes of 280 patients treated with either FMT or rectal bacteriotherapy (RBT) over five years, focusing on survival, hospitalization, and onset of certain diseases.
  • * Results showed no significant differences in survival rates, hospital admissions, or the development of specific diseases between patients treated with FMT and those who received RBT.

Article Abstract

Faecal microbiota transplantation (FMT) is the recommended treatment for recurrent infection (rCDI) following a second recurrence. FMT is considered safe in the short term when procedures for the screening of donors and transferred material are followed. However, the long-term safety profile of FMT treatment is largely unknown. In a retrospective cohort study, we assessed the long-term safety of patients treated for rCDI with FMT or a fixed bacterial mixture, rectal bacteriotherapy (RBT). The overall survival, risk of hospital admission, onset of certain pre-specified diseases (cancer, diabetes mellitus, hypertension and inflammatory bowel disease) and risk of being diagnosed with a multidrug-resistant organism were assessed by undertaking a review of the treated patients' medical records for up to five years following treatment. A total of 280 patients were treated for rCDI with FMT ( = 145) or RBT ( = 135) between 2016 and 2020. In the five years following treatment, there were no differences in survival (adjusted hazard ratio (aHR) 1.03; 95% CI 0.68-1.56), = 0.89), risk of hospital admission ((aHR 0.92; 95% CI 0.72-1.18), = 0.5) or onset of any of the analysed diseases. In conclusion, FMT was not associated with increased mortality, risk of hospital admission or onset of disease following treatment when compared with RBT.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8834574PMC
http://dx.doi.org/10.3390/cells11030435DOI Listing

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