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Golgi Apparatus Regulates Plasma Membrane Composition and Function. | LitMetric

Golgi Apparatus Regulates Plasma Membrane Composition and Function.

Cells

Istituto di Endocrinologia e Oncologia Sperimentale (SS), Consiglio Nazionale delle Ricerche, 80131 Napoli, Italy.

Published: January 2022

AI Article Synopsis

Article Abstract

Golgi apparatus is the central component of the mammalian secretory pathway and it regulates the biosynthesis of the plasma membrane through three distinct but interacting processes: (a) processing of protein and lipid cargoes; (b) creation of a sharp transition in membrane lipid composition by non-vesicular transport of lipids; and (c) vesicular sorting of proteins and lipids at the trans-Golgi network to target them to appropriate compartments. We discuss the molecules involved in these processes and their importance in physiology and development. We also discuss how mutations in these molecules affect plasma membrane composition and signaling leading to genetic diseases and cancer.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8834378PMC
http://dx.doi.org/10.3390/cells11030368DOI Listing

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