Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/s0065-2776(08)60011-5 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Effects of carbon black particles on human monocyte-derived macrophages: type-dependent pro-inflammatory activation in vitro.
Arch Toxicol
November 2024
Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine, Santariškių st. 5, 08406, Vilnius, Lithuania.
Carbon black is a key component of air-borne particulate matter, linked to adverse health outcomes, such as increased susceptibility to respiratory infections and chronic pulmonary disease exacerbations. Fine and ultrafine particles can penetrate the lungs, enter the bloodstream, and induce pathogenetic events. Macrophages play a crucial role in responding to inhaled particles, including carbon black, by initiating an innate immune response and upregulating pro-inflammatory cytokines and anti-oxidative enzymes.
View Article and Find Full Text PDFSNX17 Regulates Antigen Internalisation and Phagosomal Maturation by Dendritic Cells.
Immunology
January 2025
Instituto de Histología y Embriología de Mendoza (IHEM), Universidad Nacional de Cuyo, CONICET, Mendoza, Argentina.
Antigen cross-presentation is the process whereby small peptides derived from exogenous antigens are attached to MHC-I molecules triggering CD8+ T lymphocyte activation. The endocytic route of dendritic cells (DCs) is highly specialised for cross-presentation to initiate cytotoxic immune responses against numerous intracellular pathogens and tumours. In this study, we identify the endosomal protein sorting nexin (SNX) 17 as a key regulator of antigen internalisation and cross-presentation by DCs.
View Article and Find Full Text PDFThe vacuolar anti- activity of neutrophil primary granule peptidyl-arginine deiminase enzymes.
Front Immunol
November 2024
Pulmonary Clinical Science, Department of Anaesthesia and Critical Care Medicine, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland.
The role of neutrophils in host defense involves several cell processes including phagocytosis, degranulation of antimicrobial proteins, and the release of neutrophil extracellular traps (NETs). In turn, dysregulated cell activity is associated with the pathogenesis of airway and rheumatic diseases, in which neutrophil-derived enzymes including peptidyl-arginine deiminases (PADs) play a role. Known physiological functions of PADs in neutrophils are limited to the activity of PAD isotype 4 in histone citrullination in NET formation.
View Article and Find Full Text PDFBarriers that Inhaled Particles Encounter.
J Aerosol Med Pulm Drug Deliv
October 2024
Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Science Center, Amarillo, Texas, USA.
Article Synopsis
- Inhalable drug carriers, such as nano- and micro-particles, liposomes, and micelles, need to be specifically designed for effective drug delivery in the lungs while managing desired drug release properties.
- For these particles to effectively reach their target site in the lung, they must navigate various defenses, including mucociliary clearance and immune responses like phagocytosis by macrophages.
- Understanding the mechanical, chemical, and immunological barriers of the respiratory system is crucial for particle engineers to optimize drug carrier design and enhance the therapeutic efficacy of inhaled medications.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!