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| http://dx.doi.org/10.1159/000522588 | DOI Listing |
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SARS-CoV-2 pathophysiology and post-vaccination severity: a systematic review.
Immunol Res
December 2024
Department of Zoology, Deshbandhu College, University of Delhi, New Delhi, 110019, India.
Currently, COVID-19 is still striking after 4 years of prevalence, with millions of cases and thousands of fatalities being recorded every month. The virus can impact other major organ systems, including the gastrointestinal tract (GIT), cardiovascular, central nervous system, renal, and hepatobiliary systems. The resulting organ dysfunction from SARS-CoV-2 may be attributed to one or a combination of mechanisms, such as direct viral toxicity, disruptions in the renin-angiotensin-aldosterone system (RAAS), thrombosis, immune dysregulation, and ischemic injury due to vasculitis.
View Article and Find Full Text PDFSyncopes, paresis and loss of vision after COVID-19 mRNA-based vaccination and SARS-CoV-2 infection.
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December 2024
Goethe University Frankfurt, University Hospital Frankfurt, Department II of Internal Medicine, Infectious Diseases, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany.
mRNA-based vaccines played a key role in fighting the global COVID-19 pandemic by saving millions of lives. In rare cases, however, the BNT162b2 vaccine has been associated with severe adverse reactions e.g.
View Article and Find Full Text PDFMyocarditis Associated with COVID-19 Vaccination.
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October 2024
Institute of Heart Diseases, Faculty of Medicine, Wroclaw Medical University, 50-556 Wroclaw, Poland.
Myocarditis after the COVID-19 vaccine is one of the important adverse events following immunization, observed mainly after mRNA-based vaccines. Importantly, post-vaccination myocarditis was less common than myocarditis after SARS-CoV-2 infection, as it was scored at 19.7 per 1,000,000 doses and 2.
View Article and Find Full Text PDFCryptic late-onset myocarditis after coronavirus vaccination.
FASEB J
July 2024
Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada.
As we enter a new era of mRNA-based therapeutics, evidence on genetic or environmental factors that might predispose to unknown off-target side effects, gains in importance. Among these factors, exercise appears likely to have influenced otherwise cryptic cases of early-onset postvaccination myocarditis. And the existence of a distinct late-onset myocarditis is now being recognized.
View Article and Find Full Text PDFThe central role of natural killer cells in mediating acute myocarditis after mRNA COVID-19 vaccination.
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Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, School of Clinical Medicine, The University of Hong Kong, Hong Kong SAR, China. Electronic address:
Background: Vaccine-related acute myocarditis is recognized as a rare and specific vaccine complication following mRNA-based COVID-19 vaccinations. The precise mechanisms remain unclear. We hypothesized that natural killer (NK) cells play a central role in its pathogenesis.
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