Hydrazone-based molecular switches serve as efficient ratiometric pH-sensitive agents that can be tracked with F NMR/MRI and H NMR. Structural changes induced between pH 3 and 4 lead to signal appearance and disappearance at H and F NMR spectra allowing ratiometric pH measurements. The most pronounced are resonances of the CF group shifted by 1.8 ppm with F NMR and a hydrazone proton shifted by 2 ppm with H NMR.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8892427 | PMC |
| http://dx.doi.org/10.1021/acs.analchem.1c04978 | DOI Listing |
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