AI Article Synopsis

  • Cryptosporidium parvum is a parasitic pathogen causing diarrheal illness in humans and animals globally, and an outbreak related to this pathogen was investigated in raccoons and rehabilitation workers in Virginia.
  • In the outbreak, 15 of 49 facility staff showed symptoms, with four confirmed cases; several juvenile raccoons also exhibited diarrhea, and six were confirmed to have the same infection.
  • The same molecular subtype of the parasite was found in both human and raccoon cases, indicating possible zoonotic transmission, highlighting raccoons as a potential reservoir for human infections of C. parvum.

Article Abstract

Cryptosporidium parvum is a parasitic zoonotic pathogen responsible for diarrheal illness in humans and animals worldwide. We report an investigation of a cryptosporidiosis outbreak in raccoons and wildlife rehabilitation workers at a Virginia facility. Fifteen (31%) of 49 facility personnel experienced symptoms meeting the case definition, including four laboratory-confirmed cases. Seven juvenile raccoons were reported to have diarrhoea; six had laboratory-confirmed cryptosporidiosis. Cryptosporidium parvum of the same molecular subtype (IIaA16G3R2) was identified in two human cases and six raccoons. Raccoon illness preceded human illness by 11 days, suggesting possible zoonotic transmission from raccoons to humans. This appears to be the first report of a human cryptosporidiosis outbreak associated with exposure to raccoons infected with C. parvum. Raccoons might be an under-recognized reservoir for human C. parvum infections. Further study is needed to explore the prevalence of cryptosporidial species in raccoons and their role as a wildlife reservoir.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9178948PMC
http://dx.doi.org/10.1111/zph.12924DOI Listing

Publication Analysis

Top Keywords

cryptosporidium parvum
12
outbreak associated
8
raccoons
8
raccoons wildlife
8
cryptosporidiosis outbreak
8
parvum outbreak
4
associated raccoons
4
wildlife facility-virginia
4
facility-virginia may-june
4
may-june 2019
4

Similar Publications

Structural analyses of Cryptosporidium parvum epitopes reveal a novel scheme of decapeptide binding to H-2K.

J Struct Biol

January 2025

State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, PR China. Electronic address:

Cryptosporidium has gained much attention as a major cause of diarrhea worldwide. Here, we present the first structure of H-2K complexed with a decapeptide from Cryptosporidium parvum Gp40/15 protein (Gp40/15-VTF10). In contrast to all published structures, the aromatic residue P3-Phe of Gp40/15-VTF10 is anchored in pocket C rather than the canonical Y/F at P5 or P6 reported for octapeptides and nonapeptides.

View Article and Find Full Text PDF

Background: The determinants of differences in host infectivity among Cryptosporidium species and subtypes are poorly understood. Results from recent comparative genomic studies suggest that gains and losses of multicopy subtelomeric genes encoding insulinase-like proteases (INS-19 and INS-20 in Cryptosporidium parvum and their orthologs in closely related species) may potentially contribute to these differences.

Methodology/principal Findings: In this study, we investigated the expression and biological function of the INS-19 and INS-20 of C.

View Article and Find Full Text PDF

is a common, waterborne gastrointestinal parasite that causes diarrheal disease worldwide. Currently there are no effective therapeutics to treat cryptosporidiosis in at-risk populations. Since natural products are a known source of anti-parasitic compounds, we screened a library of extracts and pure natural product compounds isolated from bacteria and fungi collected from subterranean environments for activity against .

View Article and Find Full Text PDF

Prevalence of , and spp. in diarrhoeic suckling calves from north-western Spain and analysis of their interactions.

Int J Vet Sci Med

January 2025

Galicia (Grupo INVESAGA). Departamento de Patología Animal. Facultad de Veterinaria, Universidade de Santiago de Compostela, Lugo, Spain, Investigación en Sanidad Animal.

Although , and some species are frequently involved in neonatal calf diarrhoea (NCD), detailed studies on their interactions are scarce. Therefore, a cross-sectional study including faecal samples from 404 diarrhoeic calves aged 0-30 days was performed. oocysts and cysts were detected by immunofluorescence antibody test and positive samples were molecularly characterized.

View Article and Find Full Text PDF

Molecular characterization and zoonotic risk assessment of spp. in Philippine bats.

Food Waterborne Parasitol

March 2025

Laboratory of Sustainable Animal Environment, Graduate School of Agricultural Science, Tohoku University, Osaki, Miyagi, Japan.

is a genus of parasitic protozoa known to cause diarrheal disease that impacts both humans and animals through infection of various vertebrate species. Bats are recognized as reservoirs for zoonotic pathogens, including . The Philippines, renowned for its rich biodiversity, is home to diverse bat species, providing a unique ecological setting to investigate infection dynamics.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!