Synthesis and Toxicological Effect of Some New Pyrrole Derivatives as Prospective Insecticidal Agents against the Cotton Leafworm, (Boisduval).

Herein, a series of biologically active pyrrole derivatives, namely 2-[(3-cyano-5-aryl-1-pyrrol-2-yl)thio]acetic acids , 2-[(2-hydroxyethyl)-thio]-5-aryl-1-pyrrole-3-carbonitriles , and 2-[(2-amino-ethyl)thio]-5-aryl-1-pyrrole-3-carbonitriles , 2,2'-disulfanediylbis(5-aryl-1-pyrrole-3-carbonitriles) , 2-((3-cyano-5-aryl-1-pyrrol-2-yl)thio)acetates , 2-[(3-cyano-5-phenyl-1-pyrrol-2-yl)thio]acetohydrazides , and 2-{2-[(3-cyano-5-aryl-1-pyrrol-2-yl)thio]acetyl}--phenyl-hydrazinecarbothioamides , as insecticidal agents, were synthesized via adaptable, smoothly accessible 2-(2-oxo-2-arylylethyl)malononitriles . The structures were proved using infrared (IR), nuclear magnetic resonance (NMR), and mass spectrum (MS) techniques. Under laboratory conditions, the toxicological characteristics were tested towards , cotton leafworm insect type. In respect to the LC values, compounds , , , and possess the highest insecticidal bioefficacy, with values of 0.5707, 0.1306, 0.9442, and 5.883 ppm, respectively. The study paves the way towards discovering new materials for potential use as insecticidal active agents.