Background: Skull base osteomyelitis (SBO) is an infection of the central cranial bones, most commonly resulting from contiguous spread of infection from adjacent head and neck structures. SBO is a well-recognized complication of treatment of head and neck cancer (HNC) that results in significant morbidity.
Methods: We conducted a retrospective chart review of HNC patients diagnosed with SBO.
Results: SBO was commonly diagnosed with nasal endoscopy showing mucosal breakdown between the naso/oropharynx and skull base and with characteristic changes on CT/MRI. Culture data were often polymicrobial, inclusive of naso/oropharyngeal flora, but half of the patients additionally had antibiotic-resistant or atypical pathogens. The mean duration of antimicrobial therapy was 117 +/- 94 days. Recurrent SBO was found in half of the patients, associated with and with persistent defects in the mucosa abutting the skull base.
Conclusions: Diagnosis and management of SBO in HNC patients are challenging. Recommendations to aid in clinical care are proposed.
Level Of Evidence: 4, case series.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8823154 | PMC |
| http://dx.doi.org/10.1002/lio2.719 | DOI Listing |
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