Objectives: Atrophic rhinitis (AR) and empty nose syndrome (ENS) are chronic diseases characterized by a paradoxical nasal obstruction. These rare syndromes tend to occur after nasal surgery of the inferior turbinates in ENS and can be idiopathic in AR. Medical treatments alone are often insufficient. Surgical options are challenging and numerous resorbable and nonresorbable implants have been described in small series, with as many surgical techniques described. Whereas current surgical procedures are for risk of extrusions, graft rejections or poor lasting results, the use of GlassBONE™ (Sodimed®, Avignon, France), a bioactive glass, for a vestibular approach in AR and ENS has never been reported for this indication.
Methods: We described an original technique of nasal submucoperiosteal bilateral ceramic glass implantation in two patients with AR and ENS.
Results: The two cases presented a postoperative satisfying endoscopic and sinus CT-scan results with filling of the nasal cavities, with less crusts and a complete wound healing. They had no short-term complications.
Conclusion: This innovative approach is easily feasible and could be an option considered for the surgical management of AR and ENS. 4.
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http://dx.doi.org/10.1002/lio2.713 | DOI Listing |
Polymers (Basel)
December 2024
Department of Applied Science and Technology, Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129 Torino, Italy.
In this study, we present novel, vitrimeric and biobased scaffolds that are designed for hard tissue applications, composed of acrylated, epoxidized soybean oil (AESO) and reinforced with bioactive glass that is Tellurium doped (BG-Te) and BG-Te silanized, to tune the mechanical and antibacterial properties. The manufacture's method consisted of a DLP 3D-printing method, enabling precise resolution and the possibility to manufacture a hollow and complex structure. The resin formulation was optimized with a biobased, reactive diluent to adjust the viscosity for an optimal 3D-printing process.
View Article and Find Full Text PDFMaterials (Basel)
December 2024
Department of Engineering "Enzo Ferrari", University of Modena and Reggio Emilia, Via P. Vivarelli 10, 41125 Modena, Italy.
The development of new bioactive glasses (BGs) with enhanced bioactivity and improved resistance to crystallization is crucial for overcoming the main challenges faced by commercial BGs. Most shaping processes require thermal treatments, which can induce partial crystallization, negatively impacting the biological and mechanical properties of the final product. In this study, we present a novel bioactive glass composition, S53P4_MSK, produced by a melt-quench route.
View Article and Find Full Text PDFACS Appl Bio Mater
January 2025
Advanced Magnetic Materials Research Center, School of Metallurgy and Materials Engineering, College of Engineering, University of Tehran, North Kargar Street, Tehran 11155-4563, Iran.
Although 3D printing is becoming a dominant technique for scaffold preparation in bone tissue engineering (TE), developing hydrogel-based ink compositions with bioactive and self-healing properties remains a challenge. This research focuses on developing a bone scaffold based on a composite hydrogel, which maintains its self-healing properties after incorporating bioactive glass and is 3D-printable. The plain hydrogel ink was synthesized using natural polymers of 1 wt % N-carboxyethyl chitosan, 2 wt % hyaluronic acid aldehyde, 0.
View Article and Find Full Text PDFTissue Eng Part B Rev
January 2025
Materials Science and Engineering, School of Materials and Chemistry, University of Shanghai for Science & Technology, Shanghai, China.
Synthetic bone transplantation has emerged in recent years as a highly promising strategy to address the major clinical challenge of bone tissue defects. In this field, bioactive glasses (BGs) have been widely recognized as a viable alternative to traditional bone substitutes due to their unique advantages, including favorable biocompatibility, pronounced bioactivity, excellent biodegradability, and superior osseointegration properties. This article begins with a comprehensive overview of the development and success of BGs in bone tissue engineering, and then focuses on their composite reinforcement systems with biodegradable metals, calcium-phosphorus (Ca-P)-based bioceramics, and biodegradable medical polymers, respectively.
View Article and Find Full Text PDFBioact Mater
April 2025
Department of Oral and Maxillofacial Surgery, Affiliated Hospital of Stomatology, Nanjing Medical University, 210029, Nanjing, China.
Bone defect repair remains a great challenge in the field of orthopedics. Human body essential trace element such as copper is essential for bone regeneration, but how to use it in bone defects and the underlying its mechanisms of promoting bone formation need to be further explored. In this study, by doping copper into mesoporous bioactive glass nanoparticles (Cu-MBGNs), we unveil a previously unidentified role of copper in facilitating osteoblast mitophagy and mitochondrial dynamics, which enhance amorphous calcium phosphate (ACP) release and subsequent biomineralization, ultimately accelerating the process of bone regeneration.
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