AI Article Synopsis
- Intraoperative assessment of cerebrovascular reactivity is crucial in neurosurgery, and the study proposes using imaging photoplethysmography to measure cortical blood flow changes during CO inhalation.
- The technique's feasibility was tested on anesthetized rats with different cranial conditions, revealing that the hemodynamic response to elevated carbon dioxide levels varies based on cranial state.
- Despite variations in local and systemic blood flow changes, the study found that the ratio of changes in blood pressure and cortical perfusion can effectively indicate cerebrovascular functional reserve.
Article Abstract
Intraoperative assessment of cerebrovascular reactivity is a relevant problem of neurosurgery. To assess the functional reserve of cerebral blood flow, we suggest using imaging photoplethysmography for measuring changes in cortical perfusion caused by CO inhalation. Feasibility of the technique was demonstrated in three groups of anesthetized rats (=21) with opened and closed cranial windows. Our study for the first time revealed that the hemodynamic response to hypercapnia strongly depends on the cranial state. However, it was shown that regardless of the direction of changes in local and systemic hemodynamics, the ratio of normalized changes in arterial blood pressure and cortical perfusion could be used as a measure of the cerebrovascular functional reserve.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8803018 | PMC |
| http://dx.doi.org/10.1364/BOE.443477 | DOI Listing |
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