Objectives: The aim of this study was to determine the proportion and mechanism of resistance to ceftriaxone and ceftazidime among species and and examine the burden of methicillin-resistant from caesarean section surgical site infections in Uganda.
Methods: Wound swabs from 109 caesarean section surgical site infections were cultured for pathogenic bacteria following standard microbiological procedures. The Kirby-Bauer disc diffusion technique was used for antimicrobial susceptibility testing. Methicillin-resistant diagnosis was based on polymerase chain reaction testing for the gene. Data were analysed using SPSS-IBM Statistics v.20.
Results: A total of 118 pathogens were recovered from 93 (85%) of 109 surgical site infections swabs. Of the 118 pathogens, gram-negative bacteria were 69 (58.5%), including 44 (37.3%) species, 11 (9.3%) , 6 (5.1%) species, and 8 (6.8%) other gram-negative bacteria. In total, 49 of the 118 pathogens were gram-positive bacteria, including 34 (28.8%) and 15 (12.7%) species. Resistance to ceftriaxone was detected in all 11 (100%) of the and in 43 (97.7%) of the 44 species and to ceftazidime in all 11 (100%) of the and 40 (91%) of the 44 species. Extended-spectrum beta-lactamase explained resistance to ceftazidime in 10 (91%) of the 11 and 19 (48%) of the 40 species. Carbapenemase production explained 15 (38%) of the 40 ceftazidime-resistant species. Methicillin-resistant was detected in 91% of .
Conclusion: species, , and -majority methicillin-resistant dominated the pathogens in caesarean section surgical site infections. Almost all of the and species were resistant to ceftriaxone or ceftazidime. Extended-spectrum beta-lactamase was the underlying resistance mechanism among almost all of the ceftriaxone- or ceftazidime-resistant However, this mechanism accounted for less than half of ceftriaxone- or ceftazidime-resistant species, where carbapenemases accounted for 40% of the resistance, a finding previously unreported in Uganda.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8826261 | PMC |
| http://dx.doi.org/10.1177/2050312120970719 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Hand-Assisted Laparoscopic Surgery (HALS) as an Alternative to Unplanned Laparoscopic Conversion to Open Surgery (LCOS) in Colectomies for Acute Diverticulitis.
Surg Innov
January 2025
Morristown Medical Center, Department of Surgery, Morristown, NJ, USA.
Background: In difficult colorectal cases, surgeons may opt for a hand-assisted laparoscopic (HALS) colectomy or attempt a laparoscopic surgery that may require an unplanned conversion to open (LCOS). We aimed to compare the clinical outcomes of these 2 types of surgeries.
Methods: Colectomies for acute diverticulitis with a HALS or LCOS surgery were selected from the American College of Surgeons (ACS) National Surgical Quality Improvement Program (NSQIP) 2022 Targeted Colectomy Database.
Early MRI Can Predict the Indication for Surgery in Brachial Plexus Birth Injury: Results of the NAPTIME Study.
J Bone Joint Surg Am
January 2025
Shriners Children's Northern California, Sacramento, California.
Background: Magnetic resonance imaging (MRI) has not been routinely used for infants with brachial plexus birth injury (BPBI); instead, the decision to operate is based on the trajectory of clinical recovery by 6 months of age. The aim of this study was to develop an MRI protocol that can be performed without sedation or contrast in order to identify infants who would benefit from surgery at an earlier age than the age at which that decision could be made clinically.
Methods: This prospective multicenter NAPTIME (Non-Anesthetized Plexus Technique for Infant MRI Evaluation) study included infants aged 28 to 120 days with BPBI from 3 tertiary care centers.
Improved Risk Adjustment for Comorbid Diagnoses in Administrative Claims Analyses of Orthopaedic Surgery.
J Bone Joint Surg Am
January 2025
Department of Orthopaedic Surgery, Stanford University, Redwood City, California.
Background: The accurate inclusion of patient comorbidities ensures appropriate risk adjustment in clinical or health services research and payment models. Orthopaedic studies often use only the comorbidities included at the index inpatient admission when quantifying patient risk. The goal of this study was to assess improvements in capture rates and in model fit and discriminatory power when using additional data and best practices for comorbidity capture.
View Article and Find Full Text PDFNurses' knowledge and its determinants in surgical site infection prevention: A comprehensive systematic review and meta-analysis.
PLoS One
January 2025
Department of Nursing, College of Health Sciences, Injibara University, Injibara, Ethiopia.
Objective: The objective of this systematic review and meta-analysis is to assess and synthesize the global evidence on the level of nurses' knowledge and its determinants regarding the prevention of surgical site infections.
Methods: This systematic review and meta-analysis were conducted following strict methodological guidelines to ensure accuracy and reliability. Adhering to the 2020 PRISMA checklist, a systematic review and meta-analysis sought to establish the pooled proportion of nurse's knowledge and its determinants regarding surgical site infection prevention globally.
Regional Anesthesia and Pain Outcomes After Anterior Cruciate Ligament Reconstruction Surgery in Pediatric Patients: Society of Pediatric Anesthesia Improvement Network.
Anesth Analg
January 2025
Department of Anesthesiology and Critical Care Medicine, Johns Hopkins, All Children's Hospital, St Petersburg, Florida.
Background: Optimal perioperative pain management is unknown for adolescent patients undergoing anterior cruciate ligament reconstruction (ACLR). The study aimed to determine the association of nerve blocks with short- and long-term pain outcomes and factors influencing self-reported neurological symptoms.
Methods: We performed a multisite, prospective observational study of adolescent patients undergoing ACLR.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!