LOC102724163 promotes breast cancer cell proliferation and invasion by stimulating MUC19 expression.

Breast cancer (BC) is a malignant disease and the most commonly diagnosed cancer in women. Numerous studies have previously verified the important role of long non-coding RNAs in a number of biological processes in BC. In the present study, analysis of The Cancer Genome Atlas database and reverse transcription-quantitative PCR demonstrated that LOC102724163 expression levels were significantly upregulated in BC tissues compared to matched adjacent normal tissues and were associated with an unfavorable prognosis in patients with BC. Gain or loss of function assays indicated that overexpression of LOC102724163 significantly increased tumorgenicity and cell migration, proliferation and invasion . In the mechanistical aspect, sponged microRNA (miR)-508-5p to elevate expression. Additionally, rescue assays ascertained the function of the /miR-508-5p/ axis in the proliferation and invasion of BC cells. To the best of our knowledge, this is the first study to have demonstrated that LOC10272416 may act as a competing endogenous RNA to control MUC19 expression levels by competitively sponging miR-508-5p to modulate BC progression. Therefore, the present study has provided new insights into BC diagnosis and treatment.