RNA-Binding Protein IGF2BP1 Associated With Prognosis and Immunotherapy Response in Lung Adenocarcinoma.

N6-methyladenosine (mA) is the most common modification in eukaryotic RNAs and plays a vital role in the tumorigenesis and metastasis of various cancers. However, a comprehensive study of mA methylation regulators in lung adenocarcinoma (LUAD) is still lacking. The present study aimed to systematically explore the role of mA methylation regulators in LUAD. RNA sequencing data of 20 mA methylation regulators and clinical data of LUAD patients were downloaded from The Cancer Genome Atlas (TCGA) database. The prognosis value of mA methylation regulators in LUAD was evaluated using the Gene Expression Profiling Interactive Analysis (GEPIA) and PrognoScan database. The correlation between and immune infiltrates in LUAD was investigated via CIBERSORT and Tumor Immune Estimation Resource (TIMER). A total of 15 mA modification regulators were significantly abnormally expressed in LUAD tissues. Survival analysis revealed that four genes (, , , and ) were significantly associated with poor prognosis in LUAD. Multivariate Cox regression analysis showed that only was an independent predictor of LUAD after adjusting common clinical parameters. The mutation rates of mA modification regulators in LUAD were less than 10%. Further analysis revealed that expression was significantly correlated with immune infiltration, the expression of immune checkpoints, and tumor mutational burden (TMB) in LUAD. Our findings suggest that is an independent predictor and related to immunotherapy response in LUAD, which maybe a potential novel biomarker for LUAD prognosis and the status of tumor immunity.