The purpose of this study is to explore the impact of constraining class-specific residual variances to be equal by examining and comparing the parameter estimation of a free model and a constrained model under various conditions. A Monte Carlo simulation study was conducted under several conditions, including the number of predictors, class-specific intercepts, sample size, class-specific regression weights, and class proportion to evaluate the results for parameter estimation of the free model and the restricted model. The free model yielded a more accurate estimation than the restricted model for most of the conditions, but the accuracy of the free model estimation was impacted by the number of predictors, sample size, the disparity in the magnitude of class-specific slopes and intercepts, and class proportion. When equality constraints were imposed in residual variance discrepant conditions, the parameter estimates showed substantial inaccuracy for slopes, intercepts, and residual variances, especially for those in Class 2 (with a lower class-specific slope). When the residual variances were equal between the classes, the restricted model showed better performance under some conditions.
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http://dx.doi.org/10.3389/fpsyg.2021.736132 | DOI Listing |
Ocul Immunol Inflamm
January 2025
Department of Neurology & Stroke, University of Tübingen, Tübingen, Germany.
Purpose: This study aims to explore the relationship between autoimmune rheumatic diseases (ARDs) and the risk of iridocyclitis (IC) using Mendelian randomization (MR) analysis.
Methods: Data of ankylosing spondylitis (AS), systemic lupus erythematosus (SLE), juvenile idiopathic arthritis (JIA), Behcet's disease (BD), and iridocyclitis were obtained from genome-wide association studies with large sample sizes. The instrumental variable utilized in this study for each exposure was the single nucleotide polymorphism.
BMC Med Res Methodol
January 2025
Department of Biostatistics and Bioinformatics, Emory University, Atlanta, Georgia, USA.
Background: Cluster randomized trials, which often enroll a small number of clusters, can benefit from constrained randomization, selecting a final randomization scheme from a set of known, balanced randomizations. Previous literature has addressed the suitability of adjusting the analysis for the covariates that were balanced in the design phase when the outcome is continuous or binary. Here we extended this work to time-to-event outcomes by comparing two model-based tests and a newly derived permutation test.
View Article and Find Full Text PDFMethods
January 2025
Institute of Cardiology, Lithuanian University of Health Sciences, Kaunas 50103, Lithuania; Department of Mathematical Modelling, Kaunas University of Technology, Kaunas 51368, Lithuania.
Gap junction (GJ) channels, formed of connexin (Cx) protein, enable direct intercellular communication in most vertebrate tissues. One of the key biophysical characteristics of these channels is their unitary conductance, which can be affected by mutations in Cx genes and various biochemical factors, such as posttranslational modifications. Due to the unique intercellular configuration of GJ channels, recording single-channel currents is challenging, and precise data on unitary conductances of some Cx isoforms remain limited.
View Article and Find Full Text PDFPLoS One
January 2025
Mathematics and Computer Science Department, Faculty of Science, Beni-Suef University, Beni-Suef, Egypt.
The Weibull distribution is an important continuous distribution that is cardinal in reliability analysis and lifetime modeling. On the other hand, it has several limitations for practical applications, such as modeling lifetime scenarios with non-monotonic failure rates. However, accurate modeling of non-monotonic failure rates is essential for achieving more accurate predictions, better risk management, and informed decision-making in various domains where reliability and longevity are critical factors.
View Article and Find Full Text PDFBackground: In spite of the interest generated by controlling variance unrelated to the content in personality measures, few studies have assessed the combined impact of acquiescence (ACQ) and correlated residuals in the factor-analytic structural solutions that serve as a basis for item calibration.
Method: This article compares three control procedures in databases that simultaneously exhibit acquiescence (ACQ) and correlated residuals: the SIREN method (Navarro-Gonzalez, et al., 2024; ACQ control), the MORGANA method (Ferrando et al.
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