Antifungal activity and toxicity of an octyl gallate-loaded nanostructured lipid system on cells and nonmammalian animals.

Octyl gallate (OG) loaded into a nanostructured lipid system (NLS) was tested for antifungal activity and and toxicity. The features of NLS-OG were analyzed by dynamic light scattering and showed adequate size (132.1 nm) and homogeneity (polydispersity index = 0.200). OG was active against spp., and NLS-OG did not affect antifungal activity. NLS-OG demonstrated reduced toxicity to lung cells and zebrafish embryos compared with OG, whereas NLS was toxic to hepatic cells. OG and NLS-OG did not show toxicity in a model at 20 mg/kg. All toxic concentrations were superior to MIC (antifungal activity). These results indicate good anti- activity and low toxicity of NLS-OG.