The present study reports the enhanced antifungal, aflatoxin B (AFB) inhibitory activities and mode of action of chitosan-based nanoencapsulated Toddalia asiatica essential oil (neTAEO). Twenty-seven different chemical components were recognized from T. asiatica essential oil (TAEO) using gas chromatography-mass spectrometry (GC-MS). The caryophyllene oxide (CO) (25.4%), and 1,3-hexadiene, 3-ethyl-2,5-dimethyl- (HED) (24.08%) were documented as significant compounds. The Z-average particles diameter (Z-APD) of the neTAEO ranged between 18.41 and 131.8 nm. The neTAEO showed enhanced and most promising antifungal and AFB inhibitory activity than TAEO. In viable maize model assay, neTAEO effectively preserved the maize from fungal invade and AFB biosynthesis. The neTAEO significantly disturbs membrane integrities of Aspergillus flavus by inhibiting ergosterol biosynthesis followed by the extreme release of ions (Mg and K) and UV-absorbing (260 and 280 nm) cellular constituents. The in-silico molecular docking showed that the major active components of TAEO viz., CO and HED were active against AFB synthesizing leading genes Ver-1 and Omt-A with docking scores ranging from -4.8 to -7.7. The obtained results confirm that neTAEO showed promising antifungal and AFB inhibitory activities; hence, it could be used as an alternative green strategy to protect food grains from fungal invade and AFB production during storage.
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http://dx.doi.org/10.1016/j.ijbiomac.2022.02.026 | DOI Listing |
Comb Chem High Throughput Screen
January 2025
Department of Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.
Aim And Objective: Magnoliae Flos (Chinese name: Xin-Yi) and Xanthii Fructus (Chinese name: Cang-Er-Zi) are Chinese herbal medicines and have been used to treat allergic rhinitis (AR). However, the therapeutic effect, active ingredients, and probable processes of a compound of Magnoliae Flos and Xanthii Fructus in the form of essential oils (CMFXFEO) in treating AR have not been reported. This study aims to determine the efficacy of the CMFXFEO on ovalbumin (OVA)-induced AR in a rat model and to use network pharmacology and molecular docking to reveal the hub genes, biological functions, and signaling pathways of CMFXFEO against AR.
View Article and Find Full Text PDFCurr Pharm Biotechnol
January 2025
Department of Zoology, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia.
Background: Benign prostatic hyperplasia is a non-malignant growth of the prostate gland; it's the most common prostatic growth in aging men. 1,8-cineole is a natural compound that is extracted from the essential oil of several aromatic plants including Eucalyptus spp. Recent studies have demonstrated the anti-inflammatory, antioxidant, and anticancer activities of 1,8-cineole.
View Article and Find Full Text PDFSci Rep
January 2025
Northwest Sichuan Gas District of Southwest Oil and Gasfield Company, Jiangyou, 621700, China.
With the wide application of hydrogen-doped natural gas (HBNG) in end users, laying pipelines in urban, comprehensive pipe corridors has become increasingly common. However, the leakage and diffusion of hydrogen-doped natural gas in confined or semi-confined spaces (e.g.
View Article and Find Full Text PDFClin Exp Dent Res
February 2025
Faculty of Chemistry and Textile Engineering, National Engineering University, Lima, Peru.
Background: Recently, products with antibacterial properties derived from medicinal plants have increased as an alternative to conventional drugs. Thus, this study aimed to formulate and evaluate the antibacterial activity of an experimental gel based on Grindelia tarapacana essential oil in a bacterial consortium.
Material And Methods: The composition of the essential oil (EO) was determined using gas chromatography-mass spectrometry (GC-MS).
Chem Biodivers
January 2025
Sari Agricultural Sciences and Natural Resources University, Rangeland Sciences, sari, IRAN, ISLAMIC REPUBLIC OF.
This study investigates the influence of environmental factors on the secondary metabolites of Stachyslavandulifolia Vahl., focusing on how soil properties, temperature, and precipitation affect the yield and chemical composition of its essential oils. The research was conducted in two domains within three rangelands in Mazandaran province, Iran.
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