AI Article Synopsis
- Ume (Japanese apricot) has been recognized in Japan for its health benefits since ancient times and is known to stimulate the differentiation of preosteoblastic cells.
- A study found that ume extracts notably increased alkaline phosphatase activity and osteocalcin (OCN) levels in preosteoblast cells, indicating stimulation of bone formation.
- Additionally, a human study showed that older adults consuming high amounts of ume had significantly higher serum OCN levels than those with lower ume intake, suggesting ume may enhance OCN production in both lab and real-world settings.
Article Abstract
The fruit of Prunus mume (ume, also known as Japanese apricot) has been used as a functional food in Japan since ancient times. We previously reported that ume stimulates the differentiation of preosteoblastic cells. Osteocalcin (OCN) is secreted by osteoblasts, and there is known association with glucolipid metabolism and cognitive function. This study sought to clarify the relationship between ume extracts and OCN production both in vitro and in vivo. Alkaline phosphatase activity and OCN level in the ethyl acetate extracts of ume-treated extracts were significantly increased in preosteoblast MC3T3-E1 cells compared with the control group. In human study, serum OCN level was significantly higher in the high ume intake group than in the low intake group in community-dwelling participants over 60 years old. These results suggest that ume has the potential to upregulated OCN production both in vitro and in vivo.
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| http://dx.doi.org/10.1093/bbb/zbac013 | DOI Listing |
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