AI Article Synopsis
- Understanding how PCP components influence axon guidance is crucial for brain development and could inform new treatments for neural repair.
- Axonal growth cones serve as an excellent experimental model due to their highly polarized structure, suggesting that findings in axon guidance may also apply to broader PCP signaling mechanisms.
- The chapter details techniques used in the study, including protein localization and trafficking, protein phosphorylation, and examining protein-protein interactions both within the same cell and between neighboring cells.
Article Abstract
Understanding biochemical and cellular mechanisms of how PCP components regulate axon guidance is important for understanding brain development and may lead to new therapeutic approaches for neural repair. Meanwhile, axonal growth cones are a highly polarized structure and are a great experimental system. Therefore, some of these novel mechanisms we are uncovering for axon guidance may be applicable for PCP signaling in general. In this chapter, we introduce some of the techniques we used or developed: (1) protein localization and trafficking; (2) protein phosphorylation; and (3) protein-protein interactions in the same cell and across the two neighboring cells.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/978-1-0716-2035-9_19 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!