Background: Detecting the beginning of cognitive decay is crucial to guarantee good management and the possible prevention of dementia progression. The present study arises from observations collected during an educational event to promote mental and physical health in which incidental neuropsychological data gathered on 290 citizens showed the importance of routine neuropsychological examination in detecting early signs of cognitive decay, since many individuals were unaware of the decrease in their cognitive efficiency. Accordingly, the availability of a screening tool that is computerized, portable, self-administrable, and sensitive to the main neurocognitive changes testifying the progression towards pathological aging is critical.
Objective: To this aim, we developed a computerized battery for the early, preclinical Diagnosis of Neurocognitive disease (DiaNe), that can be self-administered and performed autonomously by using a tablet.
Methods: DiaNe includes tests expected to evaluate the main cognitive domains involved in neurodegenerative diseases (memory, attention, executive functions) with a detailed assessment of visuospatial memory in particular.
Results: DiaNe is not just the translation of standard tests into telematics, rather it is a new tool that provides both accuracy and response time measurements, aimed to screen cognitive profile and monitor it over time, being able to detect changes in still normal performances that may be suggestive of an ongoing onset of neurocognitive disorders.
Conclusion: Here we present an investigation of DiaNe concurrent validity showing that its results are comparable to those obtained by existing paper-and-pencil neuropsychological tests, and propose that DiaNe could be a useful, quick, and economical instrument for the monitoring of cognitive aging.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.3233/JAD-215294 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Deep Learning-Based Ion Channel Kinetics Analysis for Automated Patch Clamp Recording.
Adv Sci (Weinh)
December 2024
Department of Biomedical Engineering, City University of Hong Kong, Tat Chee Avenue, Kowloon Tong, Kowloon, Hong Kong SAR, China.
The patch clamp technique is a fundamental tool for investigating ion channel dynamics and electrophysiological properties. This study proposes the first artificial intelligence framework for characterizing multiple ion channel kinetics of whole-cell recordings. The framework integrates machine learning for anomaly detection and deep learning for multi-class classification.
View Article and Find Full Text PDFMultidimensional internet use related to cognitive performance in older persons: a nationwide cross-sectional study.
Front Public Health
December 2024
School of Pharmaceutical Economics and Management, Anhui University of Traditional Chinese Medicine, Hefei, China.
Introduction: The internet has been increasingly recognized as a potential driver for enhancing cognitive functioning in older adults; however, the mechanisms underlying this relationship remain insufficiently understood in the literature. This study aimed to investigate the associations between different dimensions of internet use-activity, device, and frequency-and cognitive performance in older adults.
Methods: This cross-sectional study utilized data from the fourth wave of the China Health and Retirement Longitudinal Study (CHARLS), involving a nationally representative sample of 17,676 participants aged 60 years and above.
Correlates of neurocognitive performance in older adults with chronic pain and negative emotions: baseline data from the problem adaptation therapy for pain (PATH-pain) randomized controlled trial.
Front Pain Res (Lausanne)
December 2024
Department of Psychiatry, Weill-Cornell Institute of Geriatric Psychiatry, Weill Cornell Medicine, White Plains, NY, United States.
Chronic pain is highly prevalent among older adults, is associated with cognitive deficits, and is commonly treated in primary care. We sought to document the extent of impairment across specific neurocognitive domains and its correlates among older adults with chronic pain in primary care. We analyzed baseline data from the Problem Adaptation Therapy for Pain trial, which examined a psychosocial intervention to improve emotion regulation in 100 adults ≥ 60 years with comorbid chronic pain and negative emotions, who did not have evidence of moderate-to-severe cognitive impairment.
View Article and Find Full Text PDFProton therapy versus conventional radiotherapy for the treatment of cavernous sinus benign meningioma, a randomized controlled phase III study protocol (COG-PROTON-01).
BMC Cancer
December 2024
ISTCT UMR 6030-CNRS, Université de Caen-Normandie, Caen, 14000, France.
Background: Proton therapy (PRT) is an innovative radiotherapeutic modality for the treatment of cancer with unique ballistic properties. The depth-dose distribution of a proton beam reduces exposure of healthy tissues to radiations, compared with photon-therapy (XRT). To date, only few indications for proton-therapy, like pediatric cancers, chordomas, or intra-ocular neoplasms, are reimbursed by Health systems.
View Article and Find Full Text PDFA prediction approach to COVID-19 time series with LSTM integrated attention mechanism and transfer learning.
BMC Med Res Methodol
December 2024
School of Public Health, Xuzhou Medical University, No. 209 Tongshan Road, Xuzhou, Jiangsu, 221004, China.
Background: The prediction of coronavirus disease in 2019 (COVID-19) in broader regions has been widely researched, but for specific areas such as urban areas the predictive models were rarely studied. It may be inaccurate to apply predictive models from a broad region directly to a small area. This paper builds a prediction approach for small size COVID-19 time series in a city.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!