AI Article Synopsis
- The study focuses on using 3D DNA origami, specifically hexagonal prism DNA origami (HDO), to create complex nanostructures through reliable orthogonal bonding.
- Each HDO building block features twelve carefully designed directional valences, allowing for enhanced and diverse bonding options while reducing unwanted interactions.
- This method simplifies the construction of various hierarchical nanoarchitectures and offers potential for developing functional superstructures in nanotechnology.
Article Abstract
Reliable orthogonal bonding with precise and flexible orientation control would be ideal for building finite complex nanostructures via self-assembly. Employing a three-dimensional (3D) DNA origami, hexagonal prism DNA origami (HDO), as building block, we demonstrate it is practical to construct finite hierarchical nanoarchitectures with complicated conformations through orthogonal and directional bonding. The as-designed HDO building block has twelve prescribed directional valences in 3D space and each of them supports two opposite orientations, yielding the capability to generate abundant directional bonding. Meanwhile, we minimize the thorny non-specific interactions among HDOs and enable the orthogonal bonding between any two valences based on self-similar designing. Consequently, various hierarchical nanostructures are prepared at will simply by the combination of HDOs with appropriate valences. We believe this route towards hierarchically assembly is inspiring and hope it will facilitate the fabrication of functional superstructures.
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| http://dx.doi.org/10.1002/anie.202116416 | DOI Listing |
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